Small cell carcinoma is centrally located and associated with tobacco use. It is a neoplasm of neuroendocrine cells and is associated with numerous paraneoplastic syndromes, including Cushing syndrome, syndrome of inappropriate ADH (SIADH) (resulting in hyponatremia), Lambert-Eaton myasthenic syndrome caused by presynaptic calcium channel antibody production, paraneoplastic limbic encephalitis, and subacute cerebellar degeneration.
Squamous cell carcinoma (of many different organs) result in hypercalcemia because of increased production of paraneoplastic parathyroid hormone-related peptide (PTHrP).
submitted by โshak360(19)
Paraneoplastic syndromes
Small cell carcinoma is centrally located and associated with tobacco use. It is a neoplasm of neuroendocrine cells and is associated with numerous paraneoplastic syndromes, including Cushing syndrome, syndrome of inappropriate ADH (SIADH) (resulting in hyponatremia), Lambert-Eaton myasthenic syndrome caused by presynaptic calcium channel antibody production, paraneoplastic limbic encephalitis, and subacute cerebellar degeneration.
Squamous cell carcinoma (of many different organs) result in hypercalcemia because of increased production of paraneoplastic parathyroid hormone-related peptide (PTHrP).