Pyruvate Kinase defect leads to decreased ATP leading to rigid RBCs and extra vascular hydrolysis. Increased levels of 2,3-BPG decreases hemoglobin affinity for O2.
For this one you just had to know the glycolysis pathway. Stem told you 2,3-BPG is elevated, which is upstream of pyruvate kinase.
neonemRight, and that glycolytic enzyme deficiencies lead to hemolytic anemias.+22019-05-29T01:56:12Z
toxoplasmabartonellaI just thought the typical presentation of pyruvate kinase deficiency would be hemolytic anemia of the newborn. +22020-01-09T03:26:50Z
PEP --> Pyruvate (last step of Glycolysis) second ATP producing step
Mature RBC require pyruvate kinase without it they depend on the anaerobic generation of ATP
With insufficient ATP, all active processes in the cell come to a halt. Sodium potassium ATPase pumps are the first to stop: increase intracellular K+, water leaves cell with Na+. Cell Shrinks & dies. Body is deficient in RBC + destroyed by lack of ATP = Hemolytic Anemia
Inheritance: AR
b1ackcoffeeermm . buddy, stopping NaKATPase causes RISE in intracellular Na, cell SWELLS and dies.+2020-02-13T18:18:19Z
to snoo-finity ... and beyond!
submitted by est88(10), 2019-05-13T20:40:51Z
Pyruvate Kinase defect leads to decreased ATP leading to rigid RBCs and extra vascular hydrolysis. Increased levels of 2,3-BPG decreases hemoglobin affinity for O2.