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NBME 19 Answers

nbme19/Block 0/Question#0

During an experiment, an isolated skeletal muscle ...


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When a muscle runs out of fuel (eg, glucose) and/or producing less ATP and “increased” accumulation of metabolites (all other options besides the correct choice), it is a sign of onset of muscle fatigue. The stem is asking which of the following will “decrease?”, and it is the pH that will decrease (acidosis) due to the accumulation of lactic acid (remember glycolysis pathway where pyruvate gets converted to lactic acid).