NBME Answers : doida's page

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submitted by okokok1(38), visit this page

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I think this is another prime example of NBME not expecting you to know every small detail but instead just answer their question straightforwardly. The question said "...involved in reproducible changes in HOX gene expression" and the only answer choice that deals with modifying gene expression is: transcription factors.

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pakimd why cant the answer be promoters? +

doida I also choose promoters +

yokoloco Because promoters are upstream from the gene locus (FA 2020 pg 41) and question says this molecule binds at numerous site +1

submitted by blueberriesyum(28), visit this page

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A 70 year old develops a progressive disinhibition syndrome with episodes of emotional outbursts, inappropriate use of language, and socially inappropriate behavior. Where is the most likely damage?

Answer: Frontal lobe disinhibition.

Bilateral amygdala (medial temporal lobe) would've been affected if it was Kluver Bucy Syndrome.

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flapjacks If you know the story of Phineas Gage, it can help +6

helppls How do you tell the difference from a frontal lobe issue and Kluver Bucy Syndrome? +1

nikitasr27 I would say the emotional and language part. The frontal lobe is very involved in emotions and the limbic system as well as in complex language concepts. Kluver Bucy would lack these aspects as the individual is “indifferent” to everything (no fear, no emotions) just like my ex +3

randi Kluver-bucy is also marked by specific behaviors like hyperphagia, hyperorality, hypersexuality. Apparently can also be associated with HSV-1 encephalitis FA2019 p499. +1

chaosawaits What am I looking at? From what viewpoint am I looking? Can anyone identify the labels? I have A is olfactory tract, C/D are optic nerves, E/F are optic tracts, G/H are substantia nigra of midbrain & still I am totally lost. +1

chaosawaits I imagine that we are viewing the front of the brain from underneath and slightly angled to expose the midbrain more easily. Obviously B is the frontal lobe. But what are I and J? +

an1 @chaosawaits I think J might be the partial lobe. the only thing confusing me is that B is the frontal lobe with the amygdala is actually in the temporal lobe... +

an1 I take that back, I thought it was Kluver body for a second but its just frontal lobe stuff lol +

pakimd can anyone explain why this is kluver bucy and not frontotemporal dementia? +

doida it is not kluver, it is frontal lobe dementia +

thatmd I and J are the temporal lobes +

submitted by solidshake(25), visit this page

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An AP is generated once the summation of charge at the axon hillock reaches a threshold voltage. Once the threshold voltage is passed, an AP is generated. However, the peak amplitude of the AP above threshold can still vary depending on the number of Na channels that are simultaneously open while the AP is present.

Thus, after the AP threshold has been reached and the AP is generated, the peak voltage attained can be reduced in amplitude if the first Na channels that opened begin to close because of a short inactivation time.

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namesthegame22 Influx of calcium from pre-syn. VG Ca++ channels. threshold membrane potential is reached, VG Na+ channels open and the depolarization propagates down the postsynaptic membrane, representing the muscle action potential. +