A nagging persistent dry cough is a common side effect of ACE-inhibitors due to bradykinin accumulation (bradykinin is normally degraded by ACE). Along with angioedema, itโs an important reason for discontinuation; the solution for both is to switch to an angiotensin II-receptor blocker (ARB) like losartan, which does not affect ACE activity directly.
submitted by โbwdc(697)
A nagging persistent dry cough is a common side effect of ACE-inhibitors due to bradykinin accumulation (bradykinin is normally degraded by ACE). Along with angioedema, itโs an important reason for discontinuation; the solution for both is to switch to an angiotensin II-receptor blocker (ARB) like losartan, which does not affect ACE activity directly.