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Retired NBME Step 2 CK Free 120 Answers

step2ck_free120/Block 3/Question#102 (reveal difficulty score)
A 47-year-old woman comes to the physician ...
Increased serum bradykinin concentrations ๐Ÿ” / ๐Ÿ“บ / ๐ŸŒณ / ๐Ÿ“–
tags: pharm cardio

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submitted by โˆ—bwdc(697)
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A nagging persistent dry cough is a common side effect of ACE-inhibitors due to bradykinin accumulation (bradykinin is normally degraded by ACE). Along with angioedema, itโ€™s an important reason for discontinuation; the solution for both is to switch to an angiotensin II-receptor blocker (ARB) like losartan, which does not affect ACE activity directly.

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