Middle-aged man with HIV presents with progressive pain and difficulty with bowel movements with a DRE showing a palpable mass in the anal canal with central ulceration most consistent with a squamous cell carcinoma
Key idea: HPV-related squamous cell carcinomas of the cervix, anus and penis are more commonly seen in HIV patients, which is why female patients with HIV should receive annual pap smears (rather than every 3-5 years)
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