Young woman with unsafe sexual practices and IVDU presents with fever, generalized lymphadenopathy and a diffuse maculopapular rash involving the palms and soles, most consistent with syphilis
Key idea: First-line treatment for syphilis is intramuscular penicillin G, with an alternative being doxycycline in patients with severe penicillin allergy
Key idea: Pregnant women with penicillin allergy should undergo penicillin desensitization because they are not allowed to use doxycycline (risk of teeth and bone abnormalities in baby)
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