Young patient with recurrent angioedema WITHOUT urticaria with a strong family history, most consistent with hereditary angioedema which is caused by C1 inhibitor deficiency leading to impaired bradykinin breakdown, with increased bradykinin โ> angioedema (similar pathophysiology to ACE-inhibitor angioedema)
Key idea: Autosomal dominant inheritance pattern
Key idea: These patients also commonly present with colicky abdominal pain and GI symptoms
submitted by โstep_prep5(246)
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