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Retired NBME Step 2 CK Form 7 Answers

step2ck_form7/Block 3/Question#30 (reveal difficulty score)
An 8-year-old boy is brought to the physician ...
C1 esterase inhibitor ๐Ÿ” / ๐Ÿ“บ / ๐ŸŒณ / ๐Ÿ“–
tags: Immuno

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submitted by โˆ—step_prep5(246)
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  • Young patient with recurrent angioedema WITHOUT urticaria with a strong family history, most consistent with hereditary angioedema which is caused by C1 inhibitor deficiency leading to impaired bradykinin breakdown, with increased bradykinin โ€“> angioedema (similar pathophysiology to ACE-inhibitor angioedema)
  • Key idea: Autosomal dominant inheritance pattern
  • Key idea: These patients also commonly present with colicky abdominal pain and GI symptoms

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