Acromegaly is associated with excessive growth hormone and IGF-1 concentrations, which lead to deranged glucose homeostasis.
This is done by increasing peripheral insulin resistance, impairing muscle and adipose uptake of glucose, and increasing lipolysis and hepatic gluconeogenesis.
Patients with acromegaly experience increased rates of DM and hypertriglyceridemia.
submitted by โnamesthegame22(14)
Acromegaly is associated with excessive growth hormone and IGF-1 concentrations, which lead to deranged glucose homeostasis.
This is done by increasing peripheral insulin resistance, impairing muscle and adipose uptake of glucose, and increasing lipolysis and hepatic gluconeogenesis.
Patients with acromegaly experience increased rates of DM and hypertriglyceridemia.