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Retired NBME 29 Answers

nbme29/Block 1/Question#35 (reveal difficulty score)
A 3-month-old boy is brought to the physician ...
Sodium-glucose cotransporter-1 (SGLT-1) ๐Ÿ” / ๐Ÿ“บ / ๐ŸŒณ / ๐Ÿ“–
tags: biochem repeat

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submitted by โˆ—namesthegame22(13)
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SGLT-1 is the cotransporter that absorbs galactose and glucose through the intestinal enterocytes. Deficiency of this enzyme manifests early in infancy as watery, acidic diarrhea and severe dehydration.

Fructose absorption is unaffected as this utilizes the GLUT-5 transporter instead.

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submitted by โˆ—namesthegame22(13)
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  • Glucose transporter-4 (GLUT-4) is an insulin-dependent transporter, which is primarily located in adipose tissue and skeletal muscle. It does not play a role in the intestinal absorption of glucose or other monosaccharides.

  • GLUT-5 is an insulin-independent transporter that absorbs fructose from the intestinal lumen.

  • SGLT1 iscotransporter that absorbs galactose and glucose through the intestinal enterocytes

  • Reducing substances in urine= defined as unabsorbed di- or monosaccharides, are present in the stool.

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