The patient's enzyme needs more substrate to achieve the same effect as the normal enzyme.
The Km is the substrate concentration at which the enzyme achieves 50% maximal concentration.
More substrate is needed in the patient to reach the 50% maximal velocity than is needed in the normal patient so it must be that there is a mutation in the enzyme that increases Km.
submitted by โshak360(21)
The patient's enzyme needs more substrate to achieve the same effect as the normal enzyme.
The Km is the substrate concentration at which the enzyme achieves 50% maximal concentration.
More substrate is needed in the patient to reach the 50% maximal velocity than is needed in the normal patient so it must be that there is a mutation in the enzyme that increases Km.