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Retired NBME 25 Answers

nbme25/Block 2/Question#37 (reveal difficulty score)
A 5-month-old boy is brought to the physician ...
Mutation of the beta-globin gene inherited from each parent ๐Ÿ” / ๐Ÿ“บ / ๐ŸŒณ / ๐Ÿ“–
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submitted by โˆ—shak360(19)
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tegraT slecl ehav 4 bloisspe tcdieoaass giaopltehso TLHA:

  • CHb dssaiee,
  • ianepAls
  • Lierv isaesde
  • ishameaslaT

AHL,T"" the nthrue dais ot ish g.retat

saheslasaTmi nac salo pseretn hwit ibphsailco n,pplsgtii rhwee na ecrhoertyyt is juts udddlem iwth dalrky ninagsti laesrung (taht od NOT ncnotia ).rion siTh si lsao enes in raotebdlicsis neia.ma teoN that in ssdeobtirailc eaaimn oyu ouwdl ese emepnPiphaer osbedi n(nicot-aoniinrg aposblihci ranluegs.)

asamTeslsaih are iesasdse fo feecvdite noigbl nish,ca hreeti ni the aaphl ro aebt oinlbg nahci. heT mtmneo you ese H2bA ,netmiendo you luhosd eb hkntiign fo ma-tieeshassat.bla To ffantrtedeiie bentewe jomra dan ornim btaeseasiahts-,lma uyo nede ot oklo ta hte muoatn fo A2bH nad bFH algncprei .bAH

shesittaame-laba irmon si lmrypraii na cpoimtasymat adseies itwh dlmi octciicmry im.naae bH lcorssoeeerihtp owssh a slaml nmuota of A2bH dna HbF dan aren anlrmo (%90) citosaotrncnne of b.AH

hTsi spnroe ahs NO AbH (an easnecb of )AHb nda decreasin ensoctntonacir of b2HA and bHF so it utms be rmoja etab aassetmlaih.

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