We said that AFP is decreased in autosomal trisomies, but it might be good to know that it is increased in Ataxia-telangiectasia (defect in the ATM gene leading to decreased IgA, spider angiomas, and ataxia) and within the realm of pregnancy, neural tube defects. In neural tube defects, neuropores fail to fuse in the 4th week leading to a persistent connection between the amniotic cavity and the spinal canal leading to an increased AFP in the amniotic fluid and maternal serum. This isn't the case in particular for spinal bifida occulta (the one with the tuft of hair) probably because of the lack of herniation. Remember that these diseases can also cause polyhydramnios (mainly anencephaly) due to the lack of a swallowing center in the brain.
AFP is also a tumor marker for Yolk sac tumors, mixed embryonal carcinomas (low yield), and hepatocellular carcinoma.
submitted by โshak360(23)
It can be re-accessed by making a purchase.
Purchase your membership here
$279$49Tihs paeg from 2A02F0 nda thore rrsesecuo hwso hatt tenicar bla lauves ni racnyepgn csrgnenei ear agcntiosid fro Tsrioym 2.1
The asye itnhg to rrbmmeee is atth in lal soaaolumt irmestosi PPPA-A si .cdederesa (In itromsy 21 w,Dno 81 asE,rddw nad 13 a,auPt PPAP ro egr-anaocensitapyscd aaplms tpreoin is es)c.edrdae
roF nowD dmsenory lfplcyisacie, e-irertrsfstimt onurutslad onommlcy sohws ricdenase nhuacl yrcnlcnstaue nda stpcilhyopa lnsaa .beno
lnFliay, in mtyoris 12 nwDo ry,nosdme the aeskmrr rae IH u,p sa in
nI oehrt or,metiiss eshte lvsaeu rea a.edceerds
$279$49