GVHD is due to DONOR T lymphocytes recognizing and targeting recipient cells (usually GI, skin, and liver) [diarrhea, maculopapular rash, hepatomegaly, jaundice]. This also means that this is a Type IV hypersensitivity such as contact dermatitis (poison ivy or a nickel allergy) and the PPD test. Sometimes this is taken advantage of (GVHD is usually seen in bone marrow transplants) in the scenario of bone marrow transplants for leukemia patients where we can yield a "graft-versus-tumor" effect.
submitted by โshak360(20)
GVHD is due to DONOR T lymphocytes recognizing and targeting recipient cells (usually GI, skin, and liver) [diarrhea, maculopapular rash, hepatomegaly, jaundice]. This also means that this is a Type IV hypersensitivity such as contact dermatitis (poison ivy or a nickel allergy) and the PPD test. Sometimes this is taken advantage of (GVHD is usually seen in bone marrow transplants) in the scenario of bone marrow transplants for leukemia patients where we can yield a "graft-versus-tumor" effect.