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NBME 23 Answers

nbme23/Block 1/Question#8

A 30-year-old man with HIV infection comes to the ...

It increases plasma concentrations of other PIs also metabolized by cytochrome P450

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submitted by step420(18),

Ritonavir inhibits CYP450! So you can use it to boost the concentration of the other Protease inhibitors by preventing their metabolism by CYP450!

mousie  who knew +1  
sympathetikey  Right on (thanks sketchy) +3  
mguan1993  MAGIC RACKS is a good mnemonic ive heard for 450 inhibitors (macrolides, amiodarone, grapefruit, cimetidine, RITONAVIR, alcohol (chronic), cipro, ketoconazole, sulfa +1  
criovoly  "CRACK AMIGOS" Cimetidine Ritonavir Amiodarone Ciprofloxacion Ketoconazole Acute alcoholism Macrolides Isoniasid Grapefruit juice Omeprazole Sulfonamides +2