NBME 20

nbme20/Block 3/Question#8

A 12-year-old girl is brought to the physician for ...

Polyubiquitination

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submitted by hayayah(229),

Atrophy is decrease in tissue mass due to decrease in size (increased cytoskeleton degradation via ubiquitin-proteasome pathway and autophagy;  decreased protein synthesis) and/or number of cells (apoptosis). Causes include disuse, denervation, loss of blood supply, loss of hormonal stimulation, poor nutrition.