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NBME 20

nbme20/Block 3/Question#6

A new drug has the following effects on the ...

Pathway labeled 'H' (Conversion of Leukotriene A4 to Leukotriene B4

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submitted by neonem(94),

Leukotriene B4 is a potent chemotactic molecule for neutrophils. Selective loss of this would have no effect on platelets, mast cells, or endothelium - these are more responsive to changes in TXA2, complement/arachidonic acid, and PGI2, respectively.

kernicterusthefrog  FA says: "Neutrophils arrive B4 others" +