NBME 20 Liposarcoma (NBME Answers)

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nbme20/Block 2/Question#36 (reveal difficulty score)
A 31-year-old man has a large, yellow, soft ...
Liposarcoma 🔍 / 📺 / 🌳 / 📖
tags: msk

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submitted by ∗hayayah(1212)

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Benign tumors are usually well-differentiated and well-demarcated, with low mitotic activity, no metastases, and no necrosis.

Malignant tumors (cancers) may show poor differentiation, erratic growth, local invasion, metastasis, and apoptosis. High mitotic activity.

Fat tumors:

Lipoma: benign, low mitotic activity
Liposarcoma: malignant, increased mitotic activity

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whossayin why can't it be a rhabdomyosarcoma? +1

charcot_bouchard Because of histology and gross appearance... very graphic description of fat cell tumor there +8

dr_cruceta because the question said irregular vacuolated cells, describing fat cells. Rhabdomyosarcoma comes from skeletal muscle. +7

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submitted by thomas(3)

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Lipomas/Liposarcomas are the commonest soft-tissue tumors in adults. The high mitotic index & infiltrative nature indicate that the mass is malignant.

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rockodude most common +1

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