NBME 20

nbme20/Block 2/Question#22

A 44-year-old woman comes to the physician for a ...

Ubiquitin ligase

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submitted by hayayah(216),

In eukaryotic cells, two major pathways—the ubiquitin-proteasome pathway and lysosomal proteolysis—mediate protein degradation.

The major pathway of selective protein degradation in eukaryotic cells uses ubiquitin as a marker that targets cytosolic and nuclear proteins for rapid proteolysis.

The other major pathway of protein degradation in eukaryotic cells involves the uptake of proteins by lysosomes and digestion by proteases.