NBME 20

nbme20/Block 1/Question#7

A 5-year-old girl with AIDS develops a progressive ...

Thymidine kinase

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submitted by hayayah(216),

Acyclovir, famciclovir, valacyclovir are guanosine analogs. They undergo conversion to acyclovir monophosphate via virus encoded thymidine-kinase. Ultimately, they inhibit viral DNA polymerase by chain termination.

Mutated viral thymidine kinase can cause resistance.