For a great little summary of the Endoplasmic Reticulum (and many other concepts in molecular biology!), see this from Alberts’ Molecular Biology of the Cell: https://www.ncbi.nlm.nih.gov/books/NBK26841/#A2204
I have an eisus tiwh hits suotqine hhwci lsoa ctnficosl hwti .rdlUWo nI edror to eb addeegdr by oomesoerpts teh sfdloiemd potrine louwd nede to eb neeprts ni het cotosyl orf noiabiutun. tI ti mludccaaeut ni het RRE nhet owh osed ti etg ?ggated losHe,ytn os .dtcie.fnlc.o
eTh FTRC otreipn is a treambramsenn otnreip. Lkie all oirsep,tn sit artnaltinos nsgbie ni eht lc;toyos atht aid,s CTRF asnnocti an etiurmnN-s l“nasgi neeq,ues”c hchwi emsan as ti is igebn nlatsr,eatd it na(d eth oeoribsm ianmkg i!)t ilwl eb aerrnptdots to teh iopasElcmnd .iumlueRtc^ttoooe!nf
As ti stge tsdeartnl,a ist hrybhoipdoc otfmsi lilw ere,emg wichh mdsebe het TFRC oritpen itiwhn teh ppihoolhidps iyarelb fo the RE tf!ilse thTa smean eth teirnop lliw vnere ngiaa be ufndo “in eth cos”oytl uebscae ti steg aeteddhr rguthho eht lbiyaer ihhwc( ,is ni ft,ca ohw all smenrabnermat norspiet mcoeeb srmatenbnmrea seropnti at hte clel eruacfs -- ehyt eahv to be emad iton mtnbeasrnarme tienospr ni hte RE ts)ifr!.
o,S eys, liatymteul, eeths eidsmdfol tisoernp will eb ctedierd rodwta a erpaostmoe orf erdngeacinlrdicyagot,/ btu htta illw pnhepa as a tlltei esvcile (or es“)molop”i; het dmesidfol ,potneri ni shti sac,e is ton ouslbelr-ewta en,sci( yb it,nfiednoi it hsa pcbihrhodoy tismof wihch egt aterddhe“ rgh”othu a ylebira to trceae the rnmanebmseart )t,trnaep hicwh mnsea you tw’no difn ti in eth oc.tolsy
\ teo!tofon \ eTh ncthihig of atic*ev erosiboms to eth isnmdolpaEc Rutuelcim is ywh ew lcal hatt area of RE g“horu Ecmsidalonp umicRuetl );ERr”( no ecnerotl iymopcc,ors atth iotscen aws spbedckele ihwt teltil sd;ot lrae,t ew hna(m)su rvodcidees ttah eesth tsdo erew ss!oimrebo
\ * \ yB avcie“t ”smbeoi,osr I jtsu aemn esobsroim in teh spesorc of rcnevgoint NmAR to !rntpoei (Whta we llac rtnlit“oan”as ;)
rFo a etagr eiltlt muyarsm fo eth loEmisnpcad muultiRce (dna mnya htero secntocp ni allomcuer yo!)b,gloi ees thsi morf ’blAsert lMueroacl Boliogy fo eth eCll:
.g:i4ntokbw.iAonwms20#KscwN.Btnp8v//2l/b1hh/o.624/
A mini-discussion of protein transport within the cell is here: https://nbmeanswers.com/exam/nbme21/742#257
nhWe ropnites bnegi maed ni the ER sid,flmo htey eccautlmau in the RE, hcihw hnte grigters etmh to eb itsp tuo iton teh scolyot dan bceoem daderged by m.rooassetep sT,uh eht cmluucotaina fo eht doimslfed oienrpt ni hte RE is errqdeiu rfo tmeh ot litmteauly be gdgeat yb uiitiunbq dan eb aeddgerd ni sepaeorm.ots
evEn fi yuo reagu tath eyth wlli be uaumciclngat ni hte yostloc ceeubsa aoetepsmosr rae ni the oolyt,cs hte utsineoq si knsagi erwhe are the rtsnpeio mgnulcautaci, ont igbne edraedgd. oS ehty c'tna uacmcutela ni opseoeamrst, ubasece thye era teeryddso in tm.eh
hTsi is frmo b:smosa dtauMte CRFT neeg 8F(5Δ0 natiot)mu → dsomldife repniot → eicdvftee itrpoen si entdiaer in eht oghru imcdepnalso mieuutlrc (rR)E fro drntdgoaiae → eadtAT-gP hdciolre nlcneha si staben on hte clle aserfuc of hlltpaeeii cllse turhuoghto eth boyd g,..(e elnsttaini nda eriyrrtsopa atlh,ieepi saewt dsan,gl rnxeeico ,eraacspn oiecenxr lsdgan fo tcridpeovure nag)ros
LTARU SEMILP.
eteh1r. era mayn ivarntas of ticsyc sfbrosii os sith tonusqie is nto taobu .haspypthy of FC
onpt2i. of qnetsoiu : reewh eosd treoinp glfinod ucrco ? se)nraw RRE
IPT : IF YUO EEKP HREESIANRCG ON VRASAINT OF FC, UYO ARE ON A THPA TO DSNESLE DOMO
lul fpheoje_b=feympX;niuwhyGhybHawwcsnnwtN/eulv/ogs?&ptg/.maQIcito:csBt3=uahl.oaa
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$279$49 65% OFFI ihntk reom gyne,rllae iteprno ogdnilf pshenap ta teh RER and teh tesm sasy eht onpreti nd’oets fldo pyorerpl. pSiclci,fylea eth tmso nmcmoo CF outitamn si a msldieodf ritpeno and eth orpenti si eedtnria ni het ERR dna tno rttseadponr to hte lcel neebmamr - AF 0912 gp 06.
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