I thnik omer ,ergalelyn iotnper dfgnlio sahnppe ta the RER dan eht stme ayss teh oritpen dest’no ldof rlpr.ypoe eil,lfccpiyaS eht smot onommc CF outntmai is a dsmldieof ineropt adn teh onrtepi si tdnaerie in het RER and not taoedtnprsr to hte lecl mbnmreea - FA 1290 pg .60

eTh TFRC epionrt is a nnreamtearbms .inpreot keiL all pneortis, tis itnaosarntl bnesig in het yolctos; that asi,d RTFC cosanitn na stmriNu-en aisnlg“ ,”eceequsn whhic smean as ti is ibeng andsl,treat ti d(na teh osirbmoe nikgam !t)i iwll eb rnepodtrtsa ot the acpElondmsi iulR^e.mutc!ofoentto

As ti egts ane,drastlt tis drobhyhocpi stomif lliw eme,reg which sebmed the CTRF riepnto nhiiwt the pphiplhidoos eiylbar of hte RE lstefi! aTht emsan eht rpoeitn lwil veern iagna eb nufdo “ni teh ostcyol” csueeba ti gtse atrddhee uohrthg eht ybilrae h(ihwc is, ni t,cfa woh all artnnmmeebsar ospitnre coeebm mraanerbtesnm psonirte at het clle cfeuasr -- tyeh eahv to eb dmae into bemenrmatrnsa tpnsoier ni eth RE f!s.)rti

So, sey, uylamitelt, sethe dimdolefs snrotipe iwll be deeidrct oadwrt a osmrteeopa for /decnrrilatidencgoy,ag utb htta lwli pnpaeh sa a llttie iseclve ro( );opl”sioem“ het fmlieodds tpeirn,o in hits eca,s is not seer-baowllut c(ei,sn yb f,enidintio ti ahs yoirhhbpcod ismfot hhicw get datederh“ hrtogu”h a laeibyr ot trecae eth mrnearmtnbase nrtae),tp whhci aensm ouy on’wt nfid it in hte oyc.ltos

\ otnofeot! \ The hcgithin fo aetc*iv msebrosio to eth Ecpiadolsnm tcmRilueu si yhw ew alcl ttah aera of ER g“uhor ilsdmpocnaE cRultuemi )”rR;(E no ctnerole sr,ompcyoic hatt senicto aws epdkclebes wiht ltilet ;otsd latr,e we msah)(nu ecivrdedos ahtt hseet tdos rwee isbrmsoo!e

\ * \ By eacvi“t r”imoeossb, I sjtu enam soireomsb in the rposces of ngtenrcvio mNAR to ionrep!t t(Wha we acll r”tanioalnt“s ;)

roF a eragt titlel usmaymr fo het dpnscmEailo meiuRlutc na(d mnay thoer snptceoc ni umelarolc iybool),!g see hist mfor ’lsAetrb rMoaclelu ogyioBl of the Cell:
Atnso./i02ikg:/w/w2#ohn.2Nv4mb.stKwnbcpBl6/o8/h.14

nheW opentsir inbge emad ni het RE sodl,mif they lcumeatuca in het RE, hhicw tenh ggirerts ehmt ot eb psit uot itno hte slotyoc adn beomce eregdadd yb oop.emsraste T,hsu het nctiulmcuaao of eht mosedifdl prnioet ni the RE is riqduree rof mhte ot lamtuteliy be tgegad by tiuiinbuq dan eb rgaddede ni m.paorssoete

eEnv fi ouy ugera ahtt ehty lliw eb auagnitcuclm in eht oystclo easecub omaprestoes rae ni eth ocos,lyt het qesituon si ngsiak ewrhe are het psoitern cctgamuinaul, ont igneb dedrdage. oS htey atnc' laeucutcma ni oerespot,sma cabuese htey ear tdsyeredo ni etmh.

ishT is rmfo s:maobs ttdaeuM TRFC egne ΔF8(05 umntaio)t → odleimfsd nrptoie → veditecef pnoeitr si rteniead in the guorh clnaomidspe lemituucr rE()R for rgioadeatdn → dPaegtA-T hderiocl hlencan si asbten no hte llec afreucs of iaipehltle cesll httrguohou the dboy g(..,e ttnlseinia nad soariyerrpt ,tihiepael awets lan,sdg eocernxi cenrspaa, nerxecoi gsalnd fo oetdriuvrecp r)nsgao

ALTRU I.PLESM

h1.tere era nmya taivansr fo yccsti ifssroib so tsih iotsenqu si tno tbauo yhsahpyp.t fo CF

p.2toni of snuetoiq : rwhee does enoiprt ofdnlgi curco ? )swrnae ERR

1. NI THSI PTEY OF FC , if ineoprt tonis lodefd prleypor in RER wlli it og tuo or iwll it lcetcaamuu ? )seawnr ti wlli uaelcacutm ni RE.R

PIT : FI UOY PEEK RCSGEEARIHN ON TIARVNSA OF C,F YUO RAE ON A ATPH TO ESLNSDE ODMO