NBME 23 Epinephrine (NBME Answers)

NBME 23 Answers

nbme23/Block 3/Question#49 (reveal difficulty score)
Genetic analyses of cells obtained on ...
Epinephrine 🔍 / 📺 / 🌳 / 📖
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submitted by ∗seagull(1933)

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Epinephrine is the only G coupled receptor activator the list. The rest are either inter-cellular or a tyrosine kinase (insulin).

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hello intracellular* correcting in case it trips someone up +9

fatboyslim Check out the signaling pathway of endocrine hormones on page 337 in FA 2020. These come up in Qs way more than I'd like, so it's worth learning them +1

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submitted by ∗krewfoo99(115)

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Epinephrine acts mostly on Beta receptors. Beta receptors are G coupled.

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baja_blast Alpha receptors are also G-coupled and are another potential site of action for Epinephrine (at high doses according to SketchyPharm Sympathomimetics) +2

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submitted by ∗b1ackcoffee(115)

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I don't know this is weird grammar or I overthought!

They asked 'whose expression is regulated by which of the following hormones?"

I knew defect is in GPCR - adrenergic receptors, whose transcription is regulated by corticosteriods. So chose hydrocortisone.

What was the defect in thought process?

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b1ackcoffee Oh, I get it now. defect in signal transduction by GPCR, not in GPCR itslef +2

xmen still wrong +

xmen While uncommon, there are some hydrophilic ligands that bind to intracellular receptors. One example is the neurotransmitter epinephrine, which also acts as a hormone. +

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submitted by ∗avicenna(12)

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Good Read https://www.khanacademy.org/science/biology/cell-signaling/mechanisms-of-cell-signaling/a/signal-perception

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submitted by ∗huszagmc(5)

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https://step1.medbullets.com/biochemistry/102006/signal-transduction

https://step1.medbullets.com/pharmacology/107011/g-protein-coupled-receptors-gpcr

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submitted by ∗diabetes(31)

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how is adrenal medulla has ACH nicotinic receptor which are ligand-gated Na/k channeles ? muscarinic ACH receptors are G-protein-coupled receptors.

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gdupgrant epinephrine acts on alpha or beta adrenergic receptors which are all G protien receptors. muscarinic receptors are also G coupled but Acetyl choline wasnt an answer choice. In the adrenal medulla the chromaffin cells are kinda like modified post ganglionic neurons and have nicotinic receptors. +

kcyanide101 I over thought this Q and went with thyroid hormone, thinking they were referring to TSH which is also G coupled +2

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