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NBME 23 Answers

nbme23/Block 3/Question#40 (reveal difficulty score)
A 38-year-old woman with hypercalcemia, ...
Area labeled โ€˜Bโ€™ (Proximal convoluted tubule) ๐Ÿ” / ๐Ÿ“บ / ๐ŸŒณ / ๐Ÿ“–
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submitted by โˆ—mcl(670)
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FA 2019 P 573 - The only part of the nephron that first aid says has an effect on PO4 3- is PCT.

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motherfucker  PTH inhibits na/PO4 cotransport -> PO4 excretion +4



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submitted by โˆ—abhishek021196(119)
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Early PCTโ€”contains brush border. Reabsorbs all glucose and amino acids and most HCO 3 โ€“ , Na + , Cl โ€“ , PO 4 3โ€“ , K + , H 2 O, and uric acid. Isotonic absorption. Generates and secretes NH 3 , which enables the kidney to secrete more H + . PTHโ€”inhibits Na + /PO 4 3โ€“ cotransport = Increased PO 4 3โ€“ excretion

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submitted by โˆ—syoung07(58)
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PTH acts on the PCT to dec Phosphate reabsorption--> more Phosphate in the urine. PTH also acts at DCT to inc Ca reabsorption. This question was focused on the Phosphate aspect of the site of action for PTH.

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