effect of glutamate antagonist on pt with acute cerebral infarction = targets NMDA receptor
decreases calcium entry into neurons = decreased excitotoxicity = promotes recovery from acute cerebral infarction.
uThog iuqot.nes
Rclela ttha Mtanmneei s('hiemazrle )drug is a DNAM Repocetr aAsoignntt hatt eplsh pnveert ttceixioyxcto yb cikgnolB +aC2 eyntr. Ttsha' owh I mrebmree this.
a picture for better understanding https://2e.mindsmachine.com/asf04.02.html
^ link is dead :( (they published a 3/e) but here is the re-route to the new site if anyone wants to dig in https://learninglink.oup.com/access/watson3e-student-resources
MNAD sorpeecrt ni isht acse aer ibeng edus fro nogl mrte intteatinoop inwhit eth narib nad uot of lla of trhee oichesc yoln ihts poerterc euss +aC
I kdipec NMAD auesbec ist’ itr,tyolmsua btu si eetrh nya eedrpe raones for hti?s
Yuo cna rwasen yb ersospc of a.iennomiilt teovp"eCiimt toraisnetc"ni emksa ouy tkhin tstomyilaur TN. rssoC otu GAAB adn nyc.eigl nI the xceotr so lm.ttuagea toacoeirMtpb doulw mane e'strhe odscen eesnrmsesg dlinvveo nad eht reteocrp woldu otn minttars lcma.uci ceHne AD.MN
sedu in olgn tmer ooneiainpttt ggaa(euln, eommy),r May saol pyla a roel ni eeng niritctrapsno in uoesnnr
)1 MAND is a Gtutmleaa ocrerpte pst 2b)yue APAM is a putbyes fo DAMN ttah si atiyinlli daacttiev by aetgmlatu re3e)leas DMNA trropesec ear dofnu enar AMAP reotpecrs ubt aer nto vactiteda by low llseve fo tgaueatml esaeerl due to a gM nio ico’g‘nblk teh 4 lnacenh) ueretnqF ocntAi aeonpiltt g&;t— ailtmoitsun fo AAPM &t—g; eozdaprlise tsop nysitapc nnoreu —&;gt eoaglvt eentddepn Mg kcblo fo NADM ctpeeorr omdeevr 5) xnufli of Ca hgrthou DMNA g&—t; cseaus neve orem AAPM stproeerc to eb tsndiree oint eth nemmbera (O:TEN APMA is norvseispe to aC nda tlaetu))6mag uaeescB heter rea meor soretcerp ot nrodpse to ,it eth llec is rmoe eovnipesrs to mtaagulet
lla teh tohers a oicimovnnteept censi heyt ahev iffticsciisic(yecpep an),gidsl NADM is eht noly vocneeeeehscnilt(n mvtpeeictio e,coetp)rr sha a lnigda stei nda ca , an nad n.e.mechg. oittcmeveip
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$279$49 65% OFFS,o for emos or,ensa terniutretmsraons is msnigoeth 'evI SWLAAY dltuesggr ti..hw. pbyalbro eucebsa I sntw'a agthut it wlle so eevnr aylrel ranlede t,i sjut nradele hgnueo orf rvtewahe ae.mx I juts dnuof isht boo otrhhgu NICB adn tis ATT!SAFCNI tIs' frmo 1020 so htigm be dlo, tbu ti saw erg.ta uYo can crheas hthuogr eth book dna ifdn het tprasceh. I rpttey chmu tsuj nwet tuhgroh lla fo het rnruietsotmentar rt.heacp opNbwg./.0k9Km.wniw9v.:thb1soc7/ihs/n/tBlon/
yM iman aaktalaGa-weu :tysetm = amjor etrciyaxto rsoanmieet.ttrnru Two ptesy of t1spe:rro )ec eipcrtamot,bo msot fo ihwch rae nirspeactyp Gi hciwh sdale ot ecardedse NMAD crrepeot yvcttiia nad srki fo i,ytictieoicxtxo ro stpsoypaictn qG pscortere thta adel ot cseeanir ,Na+ ,+K adn edcdrasee teatmlgua ascuse piaeliznroodat nad asdnecrie +gM+ lnmtceesdaip nda DAMN ererpotc ittaciyv nda kisr fo otxcitioeyixc,t adn )2 tnoipcoroi neclansh gcnuiilnd MAND dna AaAte/kaPinM ahles,ncn whihc lla walol eifonpccsni tnioac lxiu,nf utb nylo MDNA swolal aC++ flxniu and( lyon ni a oelatgv ndetnpede renman etfra ifsctiuefn piotiaznerload has cailsddep hte rhiobinti gM++ ino ni eht )lcnaeh.n
GABA and ilenygc = ithriinybo ansmertstte.rurino ) 1 G-AAAB nad AABGC- = oionitocrp heaclnsn atth elda to xfeul fo l,-C nad ipdsete itsh guicsna etanrioaolid,zp the nnuore lsilt ssayt wbleo eitnsgr tlpi.enaot GA-BAA idnigbn esti for a,ebartutibsr rds,etosi ,BGAA nad orpxtcinoi = sdiien opre of nan.clhe B-GAAA ibgindn iets fo bpednniaeozszei = ueiotds fo rpoe fo a.henlcn 2) nGcyile hnceanl is a eyrv rmlasii C-l lexuf hcnaln.e 3 ) BABA-G si a ceptmobraiot hanlenc ttah iscteaatv iG lnegdia ot edeedrcsa PMAc hhcwi cvttasaie xflufe +K shncanle and nbiitish a++C xlifnu sncelhna alniged ot hyip.aeznorlaoitpr
Bneicigo minsae = chatcemsoeainl ipamnedo oii(rdtoacnno fo odyb o,mvtmeen ,wrrade novaoi,titm e,ifmennoertc)r nprinhienpreeo (esple, kwesleasfnu, ,atoienntt fidgeen boh,evira eneephnirpi we(tsol oacntrcnoeint in NC,S) splu otoersnni les,(ep salsfne,keuw ,dreeoisnps eyixtn,a use)naa dna hieatimsn auosa(r,l ntiaetot,n ayle,lrg tseius egadma, dan aym eleicunfn bdool barin of.l)w uoOl,siybv all fo stih si in oiditnad to eacndrgrei rnsnutmrinsooiesa and tlfh,ig tifgh,r and ihtfg serpneos.
PTA dan oreht sirnpeu = rtcoatyiex st,inasmrsoni ale-socerde wiht trhoe lculsalme-oeml rseo.inturtremants esinonAde ns'ti yslclsicaal icnddesoer a smoenirruttarnet cbesuea ti 'snit dreaesloetd/res in C++a dpnendete ,rnamen utb rviddee ormf PTA freoeb nivagh na yxacoitret apiteoln.t
ycAtleiecohnl = ormja erntinrtraomutes vlindevo ni ietsrusmsonoriann avi mcinsrau adn ccnntoiii eep.crtsor
eetpiPd rnsitrestratnmeou = ymlmoocn eeesldra as dpepeoript rrgela rssuepocrr ttah ear elvcaed yb cecfsiip nszyeem atht weer ni hte asme enritomturtrsnea cleesvi nopu l.aerees evFi tspey = bnar/iugt pptesd,ei ioidpo ee,idtpps ytptuarii pei,dspt ahpoachiymlt eisergaln os,eronmh nda htoes otn sceisia.lfd mxeasElp = ecrrurpos ttah isgev eris ot ecabtsusn P os,ipuhmpca(p toorxcene, dan ITG and srdeleea omfr lsaml eatremdi PSN C brseif htta irsattnm anip dan eurptrtemea imntfor,aoni rwolpfue sep,tvnhioye eihinbdti yb oodiip pdetp)si,e ekiiunonrn ,A ondupepetier ,K dna eieoteurndpp m,maga and poidoi stedipep uilndcgni tlapn oskailald il(ek p)oihrm,ne yeihnsttc poioid ste,iaviervd adn ,dphiesonrn dyorshp,nni adn nn.eaheisklp In erglean iidpoo eptisdep ear etnesarsspd e(..i alngsaaei mhaci)sn,em evlivdon in xmolecp eobhrvisa uxsla(e ait,rantotc gvgreusbsii/saesismve brio,hse)va dan icdmlpeita hogu(th ont ne)vtieifid ni hcapcrtsiyi srreddios.
laeOvl,r nitsarsorreuenttm = type :pyste sullam-lemocle trsttmaenirs dna pde,sturienepo hwere aoleesml-culmls rmsnstrattei are asertf nad emdetia apidr pciatsyn insnsaosirmt .(ei. dronenag SSN /thtghflifhgig/rfit quick ens)rpo,se rhwee sa edsuoipetrnep lo(agn ihwt oclbioig eamisn adn seom amlsl ouecleml ratiestt)mnrs rae lreswo and teiamde ug,aalrd orodengpl iurnaeo.trsminnoss
omSe rc:uiptes .pft/emrkit.p:k.ereswhmued_oltrou_eidsviaia/nteoewrna/t_uhe/pptwhsu/rnobvcdtnm, 30i0w/hgacoa-eei/l1/.cgA/rd4taf6n43w80es-6--hsg1erAe/ertB18trtuirbbdsdpaP4.pfleegdpmo/6rb1ceaasn:6R3io/TiopG-fcelrghe0pBfstr302s9bt1n5a-u-2wau2r7i-, and l-ab.&9ih--6-ereatifaf08x/1c5dea1or1gs3e-liee6mw=atgp5w2awsd4bltrulh-:a///ftng1Ue3sw_ddp0-fxn2e;hg=nbg.7teb-bi/#/d.a
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