Quoting Dr Sattar, if an injury or cut is too deep so as the regenerative/stem cells are removed/damaged - then healing can only occur by repair. Thus, in this case, the stem cells of the lung aka Type 2 pneumocytes reside in the basement membrane - so, injury to basement membrane would damage type 2 pneumocytes and would NOT allow restoration of normal lung architecture. That's why maintenance of basement membrane integrity is the most important determining factor to distinguish whether tissue will heal by regeneration (restore normal architecture) or repair (fibrosis/scarring). Same concept can be applied to skin (basal cells) and intestines (crypt cells).
You have ot hktin oaubt ti thsi :ywa the tmaseneb mbrnemea si het ”fgciadnsfl“o on hwihc veor[aets]rit nlghiea rocsc.u So, ye,s mtse cslle (etpy II p)mnyeetosuc lowud eb dovivnel ni hatt hiealgn erscpos tbu hyet ctlon’ud rtesreo eth noalmr careuichertt n(“o o)”lnsaareiimbt ithtowu eth tsken‘eo’l of the mtneesba mmreaebn lgnetil thme wrehe to og, ni thaw iitrnecod ot gro,w chiwh wya si ,p“u” e.tc fI teh nameebst armebmne si ytdesdre,o uyo anc tisll teg legani,h tub ti t’own be gdrznioea egalhin -- litl’ eb ezdigniaosrd gnailhe, chwih osed ton aarpep as omlrna stuie.s (adgsirDnieoz engihal is eetrtb tahn on ail,hgne btu thwtiuo a B,M eth irrgnntgeaee cells td’on have nya r”ndceo“tii nad tfereorhe tn’ca strroee eht anomlr errcaut)etci.h
I ulwdo ihntk rsooeilnut nsvvoile het stem lcsle (teyp II mpunctyeeo).s Is het ncitat setebman enmrabme the nsarew sucebae ti stmlii dre?psa
can neaony lxneipa hwy ()D atimapaels si t?corincre
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