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NBME 22 Answers

nbme22/Block 2/Question#35 (reveal difficulty score)
A 45-year-old man with Li-Fraumeni syndrome ...
Decreased binding of RNA polymerase 🔍 / 📺 / 🌳 / 📖
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 +67  upvote downvote
submitted by seagull(1933)
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diD noneay nede to ader that astl eenetsnc iekl 50 msite aebuesc hte houart esseufr ot use brttee aamrm.rg sJut .friasgunrtt

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link981  hrAtou tr:enailoa t"haW is aam"mrrg? +6
qfever  idD oannye eadr iekl 50 tmsei dan ltils get ti ?wogrn O(L,L )em +22
drbravojose  ytlalAcu nevre rtsndnuade twah eht htuaor iangys at yan m.tie LLO +3
alimd  chSu a yhstit tnu.oqsie oD ew alleyr heav chsu esuqntois on teh rela maex? nI ym nopoini tehy tujs othwr uknj etoiqnus ot oetsh tamssesnse +1
nootnootpenguinn  Oh ym oessdon-g kathn oyu! I wsa so dam at hweoevr rotew siht tiysth !etiosqun G(to ti orgnw )llo +
xmen  HEYT EGIV STEOMMEI IREDW QTUNOESSI URDGNI EHT ERAL EAMX NAD!!! T'SI RTAENEPLXMEI +



 +12  upvote downvote
submitted by hello(429)
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eTh mraagmr fo hte latauc Q wsa fiugcon.sn

oT emka btrtee ess,ne ti holusd ays cWhhi" of teh fnoilgwlo is hte mtos elkily rutlse no eth npniicatsrotr of senge hatt ibhinti lecl disiiovn dna htta nintoca hte eusosncsn nseuceeeq ".TTA..A

So, teh Q is giskan baout eht 3tp5 geen and caceflslpiyi touba teh 5p3t nege trrpoome rigone.

tmroePro eoingsr have a TAAT xob ,o(vislybou mngnaie rich in T-A bsea i)rsp.a T-A ebsa ngiiapr ahs 2 dhrnyoge osbnd, hwich kaesm htem eresai ot elacev -&t;g- wlloas rof NAD rtncsartnipio ot rcocu mero ylias.e ARN lPo osed oinaptsncirtr fo NAD toni .ANR

heT erinte eQ-tms kaslt abtuo owh eain-FLrmiu si edu to a unamttoi ni pt53 e,eng gleidan to a akcl fo tomur pisssonupre i.iatycvt

oS, if teh ermoptro iegnor TTAA oxb of het tp35 gene si ,mtaeutd hten teh 5t3p egne illw ont etg sdanrbricet &t-g-; sthi si hwy three will eb esredceda NAR Plo ngibid.n ARN loP illw avhe a reucedd baiilty to bind p35t -t&g-; sesl tmour osuerrsps eneg roirptcinnats >-- sles tuomr ip.sespnrsuo

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jcmed  atth ludow eb ryolve ayes of hemt ghuhot eye rllo +
whk123  teBs .topnlnaieax +
fhegedus  adn elddsynu htinevegyr aksem ssnee D: hkTan yuo fro a grtae lnpa!xoneita :) +



 +8  upvote downvote
submitted by fenestrated(32)
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For ihts eno I itknh awth oyu had to ownk si tath npTinoritcsra &NN)R;t-D-gAA( is dmrrfeepo yb NRA o playemIt.esr asw ton NAD emeopalrys aeebusc isht one rliceeapst Ng&)-N-tDAD(A;

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fenestrated  nwebete csreiadne or aredseedc ngiibdn I dceipk edeecasdr ebcaues ti swa a mutinota ihhcw fdftecea hte grenyodh sobdn cwihh is who ucdolnsteei dnib ot ahec heotr +1
makinallkindzofgainz  ihts is hwo I gto it hirtg +



 +4  upvote downvote
submitted by yotsubato(1208)
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5p3 si atumedt nad tnac ndib het AATT o,bx os wtah asphpne ot rinntsorcapti of ibrioiyhtn epsinotr?

sI slbyiaalc waht stih iesontuq si nirtyg ot .sa.k.

oS on TATA xbo eorroptm g&t=; rceDadsee bnnidig of NRA laeroypmes

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link981  oYu idsa t,i yteh era "ynrtgi" to ska. dSlhou seu rttbee .rammarg +3
titanesxvi  This is no tfrsi di,a dan ysas ahtt het merootpr rogeni si hweer eAlpsoyeRmaNr bdnsi +1
nootnootpenguinn  nuaakH AATONT- .obx.. haktn ouy orf itsh olnepnx!tiaa +



 +3  upvote downvote
submitted by d_holles(218)
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This si a dgoo ricptue fo na renptixeem wongshi siht:

/1aruth.ue:2ics/9w0/a1ptr2tg/6tfnoiwwse/1crsel/m.

ecOnogen omevlu 6,2 epags 22122–219 0270()

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 +3  upvote downvote
submitted by dantescuttlefish(7)
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hWy si shit ton srendicae bindgni fo DAN ?laeoryspme

hsTi ituaotnm oludsh caeus ueclrlal iiindvos ei DAN iopanreltic and uaces scenedira dinginb ot inirgo arcnietpoil encseusqe ie AATT by DNA el.yoasmerp

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brise  t'Is nktlgia otaub onitatsum on eth csirtinntpora of egesn atht inhtiib het ecll svoid.ini lsoA NAR loasyeprme dnibs to eht rrepomto eigorn. +
nwinkelmann  s,oAl teh uetonqis caeiislfycpl oguhh(t ni a vyer d,ywro otuevnocdl way) esdak wath eth tcffee fo the tmuonait on ipttcaonrsinr s.aw ADN opl si ont udse ni ntorinctrpi,as it is seud ni i.ritlpeonca ANR pol is duse in cstitir.noranp In tmers of aerncsdei or srecaedde dgin,inb griangni is spoalivloe/yirpt gdrceha and erpinlo si ,toaropn/lnenlrua os there rea weefr io-ngdnHb iess,t dna huts aercddees igndibn fo the ARN .pol +1
medn00b  doClu tihs lontvoudec nsiutqoe oasl ae.tn..amth... .... iescn eth eegn ot aekm 53p is meessd pu ued to the gohenydr bodsn, NRA emaepylsro ilwl nto be eabl to bnid to maek the mNRA ... So etreh lilw eb rancec? ueBacse 5P3 si a uotrm pp.us.srse.or ememl konw nkhast ygsu +



 +3  upvote downvote
submitted by jessikasanz(9)
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tol of owdr mvtoi to aks ta"hw dibsn to eth ATAT "bxo

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 +0  upvote downvote
submitted by pipter(10)
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oDse onaeny ahev any icpcifes diae on het ehiacnmms of eht 5p3 ttinouma qtosneui indearrgg the ATTA box (eth one twih the sglnei mniao idca nsovnrocei and eth nediteffr yhndgroe )?bndiogn

I soche hte dseearcde gnbidni of ANR epoelmasyr no eht ATTA usqcneee fo esegn ahtt itinihb lecl oindsiiv easdb lelsoy on hte cfat htta 35p is a rtmuo rrsessppuo aa(k ateudmt p5t&-sg;3les intbnioiih of lsoiigtem&lptv-;udiin ni.viissdo)

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joha961  moFr a radnmo paerp I dnf,uo Au“lbaygr 5s3’p msot optntmiar ucnitfon si ot tac as a rscaptonrinit tacfor htta rtdlycie aerlgeuts phrepas eaversl dnuredh fo eht l’lces RAN soeprmlaye II PN(AR -eIdrI)ircsatnb ge.se”n So lormnyal it naseisecr NRA pol ni;nbdgi a tanoitum uldow aeesrdce ti. +1
estsosa  heT AATT bxo si aptr of eht pomtorer inroge iste ehwer ANR eaosmerypl II dna heort intarotrncips aotrcfs dnbi to AN.D A etfedc douwl eefretrho darecees diingbn fo NRA lseeoar.myp +7
mnemonia  osAl yuo can nasoer ti out (I gto ihts gnwor ubsaeec yuo vaeh ot be erlyla imo)useutlc nceis ew nwok that loss of p53 = ca.cren cCnare = ntaw mreo ellc ivodniis = tdo’n awnt ytnbiirohi enge = lsse nrinottpaircs fo said ene.g +1



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