NBME 22 Transferrin saturation and serum ferritin measurements (NBME Answers)

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NBME 22 Answers

nbme22/Block 1/Question#28 (reveal difficulty score)
A 48-year-old man comes to the physician ...
Transferrin saturation and serum ferritin measurements 🔍 / 📺 / 🌳 / 📖
tags: hemeonc

+9 upvote downvote
submitted by ∗lamhtu(139)

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Hemochromatosis associated with HLA-A3, but the appropriate screening test is serum transferrin saturation and ferritin levels

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homersimpson So when do you perform HLA testing? Is it a confirmatory test? +2

weirdmed51 HLA typing is genetic testing- so can’t be screening. Could be confirmatory +1

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submitted by ∗drmohandes(193)

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Iron accumulation causes free radical damage in organs:

Also notice patient + older brother are >40, which is when total iron body accumulates enough to cause symptoms.

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submitted by ∗keycompany(351)

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While this question stem is vague, the most likely diagnosis is Hereditary Hemochromatosis.

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+2 upvote downvote
submitted by ∗happysingh(57)

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Hemochromatosis (Auto Recessive HFE Gene on Ch.6) Labs :

↑↑ Serum Iron & Ferritin & Transferrin saturation

↓TIBC

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