need help with your account or subscription? click here to email us (or see the contact page)
join telegramNEW! discord
jump to exam page:
search for anything ⋅ score predictor (โ€œpredict me!โ€)

NBME 22 Answers

nbme22/Block 1/Question#19 (reveal difficulty score)
An 11-year-old boy has had pain in his right ...
Ewing sarcoma ๐Ÿ” / ๐Ÿ“บ / ๐ŸŒณ / ๐Ÿ“–
tags:

 Login (or register) to see more


 +12  upvote downvote
submitted by โˆ—link981(208)
get full access to all contentpick a username

Important to know here is location. Apart from learning the histologic descriptions (which are boring as shit), neoplasia in the diaphysis is consistent with Ewing sarcoma. Osteosarcoma location is at the Metaphysis.

get full access to all contentpick a username



 +6  upvote downvote
submitted by โˆ—meningitis(643)
get full access to all contentpick a username

Ewing sarcoma cells look like small blue hypercromatic cells because they are neuroectodermal origin (PNET) and are therefore undifferentiated with high N:C ratio.

Also remember 22+11 translocation (EWS gene on chromosome 22 and the FLI-1 gene on chromosome 11)

Yeah, I thought the same @praderwilli (about the concentric layers)

get full access to all contentpick a username
kevin  just for people who are taking exam this year, ewing is now understood to be mesenchymal stem cell neoplasm (uworld) +3



 +2  upvote downvote
submitted by โˆ—mcl(670)
get full access to all contentpick a username

Ewing sarcoma is the second most common bone malignancy in children. Histology is usually described as a small cell tumor with high N:C ratio.

get full access to all contentpick a username
praderwilli  Also the concentric layers of reactive bone sounded like "onion skin" to me! +9



Must-See Comments from nbme22

sacredazn on Unrearranged immunoglobulin gene
seagull on Decreased binding of RNA polymerase
seagull on Anticholinergic
liverdietrying on Release of stored thyroid hormone from a ...
keycompany on Negative nitrogen balance
kernicterusthefrog on Displacement
mcl on Area labeled โ€˜Dโ€™
joha961 on Displacement
imgdoc on Area labeled โ€˜Cโ€™ (Abducens nucleus, right)
alwaysanonymous on 25 mL/cm H2O
drdoom on 1 in 600
seagull on Glutamine
bubbles on Acute retroviral infection
yotsubato on Phase variation

search for anything NEW!