NBME 22 Human papillomavirus (NBME Answers)

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NBME 22 Answers

nbme22/Block 1/Question#6 (reveal difficulty score)
A 2-month-old boy is brought to the physician ...
Human papillomavirus 🔍 / 📺 / 🌳 / 📖
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submitted by ∗dentist(94)

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So do you ignore the distraction about his mother and consider which of the organisms can lead to nodule formation on the vocal cord?

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neovanilla yep _(ツ)_/¯ +2

agraham416 this might be a stretch, but considering that the mom was using cocaine during pregnancy may mean she's kind of wild, so I wouldn't be surprised if HPV was involved. that was my reasoning. +

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submitted by ∗seagull(1933)

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True vocal cords are often damaged in singing or yelling. THis allows HPV to enter the underlying nucleated cells. HPV 16 and 18 are common subtypes that may cause SCC.

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meningitis Out of all of the virus', HPV has a predilection for stratified squamous epithelium and there is no indication of vesicles(HSV) or linear ulcers (CMV)in the question stem. But with HPV you usually get a big/small (depending on time) unilateral nodule. You are correct to say singing and yelling can cause nodules but these would be bilateral in the and would appear differently. So if a question stem could easily have included that as an option: maybe irritation or something like that. +14

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submitted by chosened(1)

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Correct me if I m wrong but I think it's laryngeal papillomatosis. Papillomas can develop anywhere along the respiratory tract, but most often affect the larynx and the vocal cords (laryngeal papillomatosis). Not sure how HY this is but heres More info: https://rarediseases.org/rare-diseases/recurrent-respiratory-papillomatosis/

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hyperfukus yes you are definitely correct i think its a common wtf q that pops up bc there's one on uworld that asks if its true or false vocal cords and i had to hunt my prof down to figure it out... +3

hyperfukus also i think they love anything that compromises the airway +1

winelover777 Shout out to Pathoma, Respiratory chapter, Larynx section, Laryngeal Papilloma heading. Only reason I got this question right. +2

teepot123 yep dr sattar nails it ^ +1

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