The erwanLveei urBk Ptol is mayinl ernrdtpieet yb sit X dna Y retniTpetsc.he tueosinq ettsas hatt giivng B6 niscseaer eht viactity ot maonlr se,lelv ihchw aensm eht yiicvtta lhousd eb the easm sa hte oc,nenl r.Heam heirt Y rtenipcet odslhu be teh ms,ea os we era tneeewb iecchso B nda .C A and D do ton hvea hte smae Y ecepnitrt as oeng.Hrlh rmai cntcnoenirtosa fo B6 caudse itvtayic to ecmebo lrmn,ao dna so mVax ilwl otn eb ggicnahn adn ew cna aclnce A and D.A ahs a rweol Vaxm adn D ahs a mhuc ehrgih hexVT ma. eeridfnecf eneetbw B adn C si ni teirh m.K oMgvin to hte eltf on the X siax esmka the Km elowr dna llset you taht fiiayntf is er ohihgs oyu dlowu otn need mero 6B. utB ni uor sace fyniftia of hte znmeye orf B6 si lrleay w,ol chhwi si hyw ew ende a not mroe .6B
nI s,mamryu ew tnaw the meas mVxa nda a ehghri KW .me watn het alnmor"" cavtiyit mea(s xamv sa aom)nlr nda ew nede heirhg outnsam of 6B ofr ssuscce aiostffnyi of hte nemyez fro 6B si pybrlaob yver o.wl
ceiCoh B ash a 1)m-(/K aulev sleocr ot 0 hwhic nmase Km si eowlr adn nyiifaft fo the yenemz rof sit estbrastu si seupr sil wh.To kmase eesns sa iinggv rgeihh amstonu fo eth ie"ctimeptv"o sbsreautt B6 si pnlgih.e
nNeiegd herhi"g tnosietrannocc" of hte B6 rof zemeyn caivytit is horaten ywa fo aysing Km is eihgrh ecnis erom si eeuqrird fro 1/2 axmv vitiy.tca reasedcIn Km values lusert in K1/m negib leralms o(elcsr to 0 no the sx-,a)xi hhwci si stadeomrnetd in asnwre occehi B.
A nl"mrao" zmeeny ytaticiv in het cernepse of ehirgh B6 roennscntoicat seman taht amxV si nto n,gcniahg but mK is.
omeS of sehte ntisxopealna elyrla gndoi het .stom fI hte myzeen is aebl to eicsrean to alrmno tiiytvca htwi a rhgieh eevll fo eht a,sttruebs ttha enasm er’we ni a cietpitvmeo bonrhiiti utnoi.asti Citivtpeeom wlasay creosss no hte g,aphr os ew nac tinamelie A nda D.
Nwo we ayzealn .mK eW awnt amlsl ’Ksm orf tptoen .emsyezn eSiz sdeo not slaywa etartm .😉 etxcEp in sith scea we ndt’o tanw ttah cpyeon,t ew ntwa to kloo orf a a/l(yel1r big ,m)K eval(u htta is scloer ot ,rz)eo cb we tanw a aewk gib mK to eb lbae to pewoorrve teh otectmvpiei n.iibohtri oramngCpi teh aenigrnim 2 sohcci,e B has a Km lueav solecr ot rzoe so eert’sh yuro ae.rswn
oFr hist ,otqeunsi I wsa kinhtgin taht ehty kdsea you oepcarm to a “lmnaor” nosr,ep so hte xaVm udo’lwtn aecnhg sncei ethy attse atht hsi iaytivct tesurnr to a olrnam lvl.ee nlyO hte xai-sx wloud einsc it uwlod eb at eedcirsan tteancorocinns in .oonaprcsim
So i fndou htsi isnutqeo l.do.siucui.r eht iaanlposextn vioddpre idd tno lyrael lerac it up fro ,me tbu i tinkh i nrteaundsd ti now a(epels terrcoc em if i'm )nog.rw
Ftris dan ootsrmfe, m'I nto vene rsue if thsi is lryut a -lwberknaivereue t,olp eicsn teh a-Xixs si ton 1./mK
Bu,t remo ,rlnelygae I irdet ot usdraedtnn hwta dnheaepp at hobt esxeermt of ]LPP[ dan .lyecoVti
LPA: skP efy:rsulo erehw no hte pgrha is [PLP] hsteg?ih ,eWll fi het xsa-iX is laequ ot P/,P1L PPL duowl eb at its ghthsie at hte vuela lsoctse to 0 on the -ia.xsx nk:(hti wath is 1 vddiedi yb a bol?iiln VEYR ECOSL OT )EOZ.R Tsih oluwd rorpedosnc to a ionpt lgnoa eht sxyai- rfo het esmezny at.iivyct nI thero srowd, PPL si ta tsi isehght onnectatncoir at eth hgspra t.eritpnYc-e
emeerbRm awth we slao isd:a enhw eth mtutade zmenye is dnroau lost of PPL, it baaliscyl funscinot lkie a lnm yez.enm Tihs sen,ma that het aVxm of the teudatm eeymnz is lnuteqieva ot hte xVam of teh arlmon nzmy.ee eeT,hefrro hTe amx/V1 of tboh menzyse aer te.anlq..uvie ta the Tetri cthn!-esyip si bgi! fI uoy tge hits r,fa then you nca inltaemei A() nda ,()D sneic htees shgpar avhe edifnftre ctptsnee-riY ftidn(eefr -)emxVas fro irteh ptceiveser e.zyensm
gvoinM n...o
ctyVeilo )V(: ne hW V is at tis hehtsig ..(ie mVax), the vuela of /V1 wloud be ta tis e.ostlw agA:(in khnit of ti cira:ctlplya wath si 1 dddveii yb 1 i?liobnl )0~! Tf,eoherer eth uvael fo /V1 si at tsi stwoel wnhe het xysai- si uqlae ot 0. ,Toreeerfh Teh Vaxm of ihst rcoucs when het asix-y is cseol ot z..er.o rseeH het gihtn toh.. esthe seymzen uieqerr nfeteirdf llsvee of LPP ot tpaeroe at ma.V-x emr,Rebme eht a-Vxm fo the DEMTUTA eyzmne ilwl nhaepp ta a mcuh RHIHEG .]P[PL Or sv,rlecynoe het -mxVa fo eht ONRLAM myenze liwl apnehp ta a cumh EWROL .L.P[]P.
be ewaar tath eth xxis-a rfo htis suoqntie si otn ""Km B(ivt6 si ton the rtsshtea'tbta u ]/i.t1B6V[ ot iysfpim, csbeeau eht amxV si anogn tays the ase,m yuo ustj ndee ot scenarei Bt[6v]i to teg teh same axmV a(ak ihfts to igtrh no het sa.-xix) tD'n o eb dolfeo dnarou yb eht setioqun r.ritew
byoNod ahs edawresn tshi nsquteio gruthho eth lens fo a lninarge vtbeoeijc iqtue tey so eer'sh my 2 ec:snt mK si SNRIAEECD cb ihst etinatp sah an emzney tiwh na elvarol OLRWE fianytif a(nc be cotecrerd ot moanlr featr an nirseeca ni seaubrts)t hichw is hsectraiatrcic fo EPVCITOEMTI ithniib,oin wihhc is yhw het neil fo teh tp. si neo of pmtevioietc iiihnbnoit no a BL plto
Teh nsiqoeut si alsybcila itsnegt up a oautniits airilms ot taht of a poictvteiem .hontbiiri hyeT ysa atht rhiheg cconnaiotsnter fo oyarpdixl athspeohp sacesiern the iactviyt of teh zenyme ot lmarno lee.vls miiSlyra,l when uyo heav a ieviopcettm orhinbtii nda cnrsaiee the nectnctariono fo tsasuer,bt teh yezmen acn ievhaec eht msea Vxma sa if twhuoit the tihriinob.
mrmeReeb )1 imevtctoipe oisnhtribi ~ inles soCsr ta -ct)e2i nrytse t-oeeNtopimnvic ohntibiisr ~ on ienl srcso
nLog easwnr edaah, ubt erba twhi m.e
HITN: v koslo dnik of elki y, rehwsae k koslo rmoe eilk .x
tt-ecepriny = 1aV/xm
teecpnxi-tr = 1Km/
Noet atht xam,V as a asmuere fo armoe,refpcn can be telaerd hghrout yanm shgi.tn ehnai,eMlw mK si a ste iriaehtrccatcs of the ezmyn,e adn ncaotn be le.rdeta
In thsi ,xelpaem the eyenzm ereopacmrfn (Vm)ax is erdcinesa by neigrcansi eht nmvtiai cfrtacoo so htat ti crhease a rlnoa""m iictvy.ta vwee,oHr the emnyez is lstil hilnrneyet tsityh eud ot a elacingotn etfce,d so teh Km sayst eht ams.e
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