NBME 20 β-Tubulin (NBME Answers)

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NBME 20 Answers

nbme20/Block 3/Question#31 (reveal difficulty score)
A 62-year-old woman comes to the physician ...
β-Tubulin 🔍 / 📺 / 🌳 / 📖
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submitted by ∗dickass(127)

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Paclitaxel hyperstabilizes polymerized microtubules (made up of alpha- and beta- tubulin)

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md_caffeiner And clinical use is in breast and ovarian CA (FA19 433) +2

len49 TAXes stabilize society. +1

alimd Tarzan: taxanes (e.g. paclitaxel, docetaxel, cabazitaxel. SKETCHY +1

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submitted by ∗xxabi(293)

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Vinca and plant alkaloids bind B-tubulin, which inhibits the formation or disassembly or microtubules, respectively.

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md_caffeiner Vinca is a plant alkaloid and it has vinblastin, vincristine, which bind β-tubulin and inhibit its polymerization into microtubules Paclitaxel hyperstabilizes and prevents breakdown, its not a Vinca alkaloid. (FA+Wikipedia) +2

md_caffeiner What I mean is they are both derived from plants. +

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submitted by ∗celeste(96)

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Beta-Tubulin is a subunit of tubulin. Tubulin is one of several members of a small family of globular proteins. It is the major constituent of microtubules. There are two of most common members of the tubulin family: alpha-tubulin and beta-tubulin, and together their dimers form microtubules. (origene.com)

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