NBME 20 Pathway labeled 'H' (Conversion of Leukotriene A<sub>4</sub> to Leukotriene B<sub>4</sub> (NBME Answers)

need help with your account or subscription? click here to email us (or see the contact page)

search for anything ⋅ score predictor (“predict me!”)

NBME 20 Answers

nbme20/Block 3/Question#6 (reveal difficulty score)
A new drug has the following effects on the ...
Pathway labeled 'H' (Conversion of Leukotriene A₄ to Leukotriene B₄ 🔍 / 📺 / 🌳 / 📖
tags:

+3 upvote downvote
submitted by ∗neonem(629)

get full access to all content ⋅ pick a username

Leukotriene B4 is a potent chemotactic molecule for neutrophils. Selective loss of this would have no effect on platelets, mast cells, or endothelium - these are more responsive to changes in TXA2, complement/arachidonic acid, and PGI2, respectively.

get full access to all content ⋅ pick a username

kernicterusthefrog FA says: "Neutrophils arrive B4 others" +5

fatboyslim Important neutrophil chemotactic agents: C5a, IL-8, leukotriene B4 (LTB4), platelet-activating factor, and kallikrein. Source: FA 2020 page 406 +2

fatboyslim Why is choice 'C' incorrect? +

Rule out anything leading to LTC4 because mast cells release LTC4, LTD4, and LTE4 in Asthma to increase bronchial tone.

+8/- hungrybox(1277)

Must-See Comments from nbme20

amorah on Cytomegalovirus infection
masonkingcobra on Contact with parakeets
hayayah on Capillary hydrostatic: increased; ...
hayayah on X chromosome-linked isoenzymes
medbitch94 on Mannose 6-phosphate
hello on Capillary hydrostatic: increased; ...
hayayah on Osteoblasts
imgdoc on Hypophosphatemia
hayayah on Missense
celeste on 50%
justgettinby on Omeprazole
andrewk1 on Cold, dry air
yotsubato on Jugular venous pressure of 12 mm Hg
strugglebus on Drug effect