This is an older woman with sarcoidosis. This commonly happens in this demographic (usually African-American women) and presents with hypercalcemia and noncaseating granulomas.
Sarcoidosis is caused by uncontrolled active vitamin D synthesis by macrophages, leading to increased 1a-hydroxylase activity in the kidneys, leading to more vitamin D.
This increased vitamin D leads to...
-Increased Ca by increased intestinal absorption w/ no negative feedback on vitamin D
-PTH is decreased because of the negative feedback from calcium
submitted by โbingcentipede(356)
This is an older woman with sarcoidosis. This commonly happens in this demographic (usually African-American women) and presents with hypercalcemia and noncaseating granulomas.
Sarcoidosis is caused by uncontrolled active vitamin D synthesis by macrophages, leading to increased 1a-hydroxylase activity in the kidneys, leading to more vitamin D.
This increased vitamin D leads to... -Increased Ca by increased intestinal absorption w/ no negative feedback on vitamin D -PTH is decreased because of the negative feedback from calcium