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Welcome to wolvarien’s page.
Contributor score: -1


Comments ...

 -1  (step2ck_form7#3)

Ok, the idea is simple, Celecoxib is a selective COX2 inhibitor that acts only to reduce pain, while indomethacin is a non-selective cox inhibitor which beside reducing pain it also reduce neutrophil chemotaxis, thus reducing the inflammation and tissue damage in an acute attack. This is the trick in this questions+

Aspirin act as anti inflammatory only in high doses.+

Allopurinol used to chronically to reduce future attacks be reducing uric acid+

Dexamethasone is a 2nd line drug used when there is contraindications to NASID+


 -1  (step2ck_form7#3)

Ok, the idea is simple, Celecoxib is a selective COX2 inhibitor that acts only to reduce pain, while indomethacin is a non-selective cox inhibitor which beside reducing pain it also reduce neutrophil chemotaxis, thus reducing the inflammation and tissue damage in an acute attack. This is the trick in this questions+

Aspirin act as anti inflammatory only in high doses.+

Allopurinol used to chronically to reduce future attacks be reducing uric acid+

Dexamethasone is a 2nd line drug used when there is contraindications to NASID+


 +0  (free120#20)
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reveN ellt ayn intapte ot pya ymeon or ot do ghynatni to so ttha the aitophls or eht dorcot gte .iadp hTat sktiser tuo hosecic A ;m&pa E,

reevN try ot cmsa the aeusnrnic whit salef sdifingn bseuace uyo lliw fcea legla sircsns.peou Tath iesskrt uto ohicce .D

ignofnrmI hte sunanceri amynocp tuoab het sittepan' hottsguh ro oaehbvri iwll bhacer het yaircpv of hte tnepai.t ahTt trssiek uot ccohei .C

heT ynol illogac hntgi si ot oielplty lpxneai to eth tnetipa ahtt you anc not lmpyco twhi hre ee.tqusr


 -2  (nbme21#28)
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het way I utgtohh bauto ,it is hatt eht Osteesinsgeo aceeptmrfI sesltru ni vetecfdie etdioso tncudroipo ichwh is a ndrasyeco utecutsrr ot olnalegc hneitsyss


 +1  (nbme22#20)
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I am tyirgn to irfeug siht tou fomr eht inksl vridp.eod naC eoosnem lpasee lneixap hte lorntaia ehinbd hsit tnseiquo ?

p4p4y4  I believe it's that this muscle everts the foot + runs over the lateral malleolus .. But the phrasing on the question is odd +4
angelaq11  I didn't actually know this one. I just ruled out everything except the fibularis muscles, and then to be quite honest, I think I had never heard before of the tertius one, so...I chose brevis. +6
asharm10  @angelaq11 same here :D +

 +0  (nbme22#29)
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I aevh arsdenew thsi qnetiuos twih sith e hdotmeht CT is ghosinw a amss no the tf iepedplanx is on hte irtgh so tshi hcioec is grnoemu waCc si on eth hgirt os this ociceh is raohsctow gnm si on hte deimld os hist occieh si deun rnowdmugo etuoisnunctsspi eevrn hadre fo it so the lony gnhti flet is mnJeuuj





Subcomments ...

submitted by yotsubato(979),

This one made no sense. Celecoxib is already the strongest NSAID. I would rather give Dexamethasone. Which works along a seperate mechanism of action.

jaypat  Indomethacin is typically the first choice NSAID for acute gout flares. Then glucocorticoids. Lastly Colchicine +  
seagull  I also choose steroids since they were on a NSAID. fml +  
creamy  Naw dawg. Celecoxib has anti-inflammatory efficacy hence the categorization as a NSAID. In fact, gout patients treated with Celecoxib have the same treatment response as Indomethacin. Celecoxib is actually listed as an alternative to nonselective NSAIDs for acute gouty flares. This was just a bumbass question. +1  


submitted by lamhtu(113),
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eegndiN "heihgr ocnnt"orenscait fo hte 6B for myzene vyicatit is tahoner way of asgniy mK si erhhig cesin reom si rdeeirqu orf 21/ vmxa .ttavcyii arendseIc Km ulesav etlrus ni /1mK gnebi ramesll csler(o to 0 no eth x)a,-xsi hihcw is etdmrtaosdne ni arnsew ociche B.

A nrlo"m"a enzemy vcitaiyt ni eht resnepce fo gierhh B6 ctsoncnaintero esman ttah amVx si ton ,cinnhagg tbu Km si.

d_holles  In other words, Normal enzyme activity = Vmax Adding more B6 to a mutated enzyme will improve it back to normal (Vmax stays constant, so Km will decreased due to ↑ affinity of the enzyme). +  


submitted by seagull(1443),
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uto fo rutso,icyi how yma pepeol enkw h?sit tn(do be yhs ot sya uoy did or )td?ndi

yM ervypot tneoacdiu iddtn' rnngaii ihts in .em

johnthurtjr  I did not +1  
nlkrueger  i did not lol +  
ht3  you're definitely not alone lol +  
yotsubato  no idea +  
yotsubato  And its not in FA, so fuck it IMO +1  
niboonsh  i didnt +  
imnotarobotbut  Nope +  
epr94  did not +  
link981  I guessed it because the names sounded similar :D +14  
d_holles  i did not +  
yb_26  I also guessed because both words start with "glu"))) +27  
impostersyndromel1000  same as person above me. also bc arginine carbamoyl phosphate and nag are all related through urea cycle. +1  
jaxx  Not a clue. This was so random. +  
ls3076  no way +  
hyperfukus  no clue +  
mkreamy  this made me feel a lot better. also, no fucking clue +1  
amirmullick3  My immediate thought after reading this was "why would i know this and how does this make me a better doctor?" +7  
mrglass  Generally speaking Glutamine is often used to aminate things. Think brain nitrogen metabolism. You know that F-6-P isn't an amine, and that Glucosamine is, so Glutamine isn't an unrealistic guess. +4  
djtallahassee  yea, I mature 30k anki cards to see this bs +4  
taediggity  I literally shouted wtf in quiet library at this question. +1  
bend_nbme_over  Lol def didn't know it. Looks like I'm not going to be a competent doctor because I don't know the hexosamine pathway lol +21  
drschmoctor  Is it biochemistry? Then I do not know it. +4  
snoochi95  hell no brother +  
roro17  I didn’t +  
bodanese  I did not +  
hatethisshit  nope +  
jesusisking  I Ctrl+F'd glucosamine in FA and it's not even there lol +  
batmane  i definitely guessed, for some reason got it down to arginine and glutamine +1  
waterloo  Nope. +  
monique  I did not +  
issamd1221  didnt +  
baja_blast  Narrowed it down to Arginine and Glutamine figuring the Nitrogen would have to come from one of these two but of course I picked the wrong one. Classic. +1  
amy  +1 no idea! +  
mumenrider4ever  Had no idea what glucosamine was +  
feeeeeever  Ahhh yes the classic Glucosamine from fructose 6-phosphate question....Missed this question harder than the Misoprostol missed swing +1  
surfacegomd  no clue +  
schep  no idea. i could only safely eliminate carbamoyl phosphate because that's urea cycle +  
kernicteruscandycorn  NOPE! +  
chediakhigashi  nurp +  
kidokick  just adding in to say, nope. +  
flvent2120  Lol I didn't either. I think this is just critical thinking though. The amine has to come from somewhere. Glutamine/glutamate is known to transfer amines at the least +1