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Welcome to wasabilateral’s page.
Contributor score: 39

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 +13  (nbme21#28)
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I knthi it ash seogihtnm to od tiwh geylcni u(de ot tsi laslm izse it anc tif in amny sepcal wheer eroth mniao sdcai can nto and eenhc it ieropdsv turulrtcs“a ”npecsmaotsc ot teh aoegnl,cl .ie. upt a kink ni hte aahlp )l.eihx fI ygcnlei si sdealmpci yb tnsheomgi ,eels I o’ntd ihktn oplcgaeol-rn anc ofmr sti ercrcot orydcnaes ttr.sueruc

jotajota94  True! also, glycine is 1/3 of collagen alfa chains, so it makes sense that substitution with alanine (which is much bigger) would lead to disruption in the alpha helix formation. +
jotajota94  True! also, glycine is 1/3 of collagen alfa chains, so it makes sense that substitution with alanine (which is much bigger) would lead to disruption in the alpha helix formation. +
thepacksurvives  Glycine is small and bendy, which allows it to form the fibrils for the triple helix +
brasel  Also in general (FA 2018 pg 50) OI is from problems forming the triple helix which is secondary structure. Fortunately, they gave us something to reason with in the question (Gly->Ala) +1

 +7  (nbme21#39)
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hisT si hawt I uttohhg btu tno rseu fi t’is trer.coc eTerh si a WrdoUl q hrewe ti ssedcbrie iatnn-radiioctsmo fo cisortlo dan eeerihpnn.pi ooisrlCt afcnnsltgyiii anesnech hte efectf of pei scabeue locstori sah a riisemvpse cetfef no nnintmagiai eth radcegnire eescor.tpr

194orbust  per UWorld, "cortisol exerts a permissive effect on many hormones to help improve the response to a variety of stressors. For example, cortisol increases vascular and bronchial smooth muscle reactivity to catecholamines". FA also uses the effect of cortisol on catecholamine responsiveness as the lone example for a permissive drug interaction (FA2018 pg 229). The difference here is that we're talking about exogenous glucocorticoid and adrenergic agonist. I guess it was expected for us to assume that the mechanism is analogous for the analogous drugs +3
maxillarythirdmolar  I'm sure it's related to the activating effect of Cortisol on phenylethanolamine-N-methyltransferase, converting NE to Epi. Sounds like a synergistic thing to me. (FA.83) +3
feeeeeever  My logic is probably flawed, but I also thought that if cortisol has the ability inhibit COX, LOX, and NFKB you can reduce inflammation and bronchoconstrictive mediators. Therefore, the B2 agonists would have a greater effect since things like LTB4 will be reduced. +1
feeeeeever  *LTC4, LTD4, LTE4 for bronchoconstriction, my bad +1

 +15  (nbme21#2)
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spyhlSii nseapieohgst is eth iomnafatlinm adn obainioerttl fo eht avas mrvauos llmas( dbool evslses) ahtt feeds geigbr boold evesssl eilk aa,tro stree,air .eseolairtr It deos ton etrmta twah het etgas s,i .T mlulapid ftsinec het avsa srumoav na,d ni teh peor,ssc belottesira eht serevn nad obdol vesesl.s Tihs kills bolod pusply to shote aaesr = scmahiie btu on pnia spsnilae( ) erMo adezlolic ni liearre setag,s nda in telar sg,eat het etsecrohsip tamdei,seins so you vahe eht otraa and snapli ocdr lnevvtenimo but same gsost.ahepein i:d(Et naGloj nxlpdaiee tish we.homr)see

privatejoker  So is the heavily implied step-wise formation of Syphilis symptoms as presented in FA complete BS then? Why break it down into stages and have us learn it as such if this is not the case in real practice? +4
lilmonkey  Exactly, Goljan mentioned this in one of his audio lectures. All kinds of lesions in syphilis caused by vasculitis. +3

 +4  (nbme21#3)
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I thkni ethy antw you to hknti outab woh njgtaueoc anecciv si :mead raldecoacpshyi + niterop mtnragfe ot( unedci T pdneeentd mnuime enre)o.pss Onyl fgilnllea si a erinpto or( at tsale dnssuo keli en)o in hte pioton l.sit

vi_capsule  Flagellum is protein. Pilli/Fimbriae - GLycoprotein +2

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