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Comments ...

 +0  (nbme20#37)
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I on'td gte .isth t'ohdSuln eth snkiyde tasrt egirrontcc eth cbirba lsevle frea 5 dsya? heT deyaled phesa fo eht ocerorncit cseni yhet aket .m..eti and in hte qnetisuo eerhyt' agiksn w"" .noWe hvea abcmitole oialsskla censi LHC is s,lot so hte bydo iwll rty to orccrte ti irfst yb neniihalypevrtot adn erlta yb eidcrnsea rnoexceti fo rac.ibb icbraB usoldh eb .o.w.l ss(ulne Im' ginsmis gnemhtiso ued ot egibn uesexat)hd

thefoggymist  Nevermind, I think I got it. Beta intercalated cells cannot function and excrete bicarb because we don't have chloride. Yea apparently I was exhausted. +




Subcomments ...

submitted by hayayah(990),
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sesenisM uinsttaom eilvvno a cdotnuleei unttsisotiub iuerlgnts in gcdaehn onmia .acdsi mStoiesme teh etfscef of nsseeism iutatsnom may be oyln tpaerpan nurde eiantcr inetvmealnnro n;iosdtonci cuhs snmeiess mtaiousnt rae lcdeal iiacoltondn n.iuottmas nyaM nssiesem mitnutsao ueltrs ni ripntseo ttah rae tlsli ,ufincoltna at sleta to msoe ree.ged

lAos, lla eht threo anessrw woudl pyoblbra velae you htiw retehi a ltrayge aedlret or in-loaoftncnun .torpnie

thefoggymist  I chose nonsense because I thought it'll make the enzyme shorter (since less bonds = more heat liable = can't work at 42 degrees) but yea, probably won't work even at 30 if it's an early nonsense. +2  
joanmadd  A good clinically related example is HbC disease on electrophoresis. HbC disease is due to a missense mutation (glutamic acid (-) for valine (neutral)). The mutated hemoglobin is still fairly functional but when placed on gel electrophoresis the HbC migrates the least far from the negative electrode due to less negative propulsion (lack of wild type glutamic acid). +1  
fatboyslim  @Joanmadd Just to clarify, glutamic acid substitution for valine occurs in sickle cell disease not HbC. HbC is glutamic acid substitution for lysine :) +3  
rockodude  lyCCCCine for HbC +  


submitted by hayayah(990),
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tetLli ignrfe = unlra .evnre

8TC-1 rae hte osrot of the arnlu e,envr hcwhi si a rcnhba fo eth idaeml dor.c hTe nlaru eevrn si tno ndfuo in eth ralpac ennlut teh( midela ernev si.)

Ulnar n. magead anc dlea ot olss of tswir nfloxie dna o,tdudcnai xoefiln fo amdeli fe,grsni ncdoutaib dan dcanuoitd fo frgseni ti,eserso)(in coatisn of aelmid 2 mbliucrla mulessc. ssLo fo tasneisno revo demial 1 21/ sergi,nf ucnginild ptayenhroh eecmn.eni

sugaplum  Also to add: since it is a bilateral sx it is more likely to be coming from the spinal cord then from equal compression of ulnar nerve (in guyons canal) on both sides. unless she is a cyclist +20  
thefoggymist  shouldn't the other nerves of the same roots be affected? +  
thefoggymist  shouldn't the other nerves of the same roots be affected? +  
charcot_bouchard  Not really. In klumpeke paralysis ulnar nerve s/s dominates (Almost same cause) +  


submitted by hayayah(990),
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ieLttl erfnig = ralnu nevre.

-C1T8 era the rosto of het alnur rve,ne hhciw is a bnrcha of eth ealmdi orc.d Teh lnuar ernev si ont dnuof ni teh apclra nlutne hte( aeldim reevn i.s)

anlUr n. egadam acn lead to lsos fo triws liefxon dna cuntida,do ixfelon of mdlaie ,friengs nabudicot adn nucddtioa fo fenigsr n(ressoiti,e) coasnit fo iadmel 2 uarmcllib .esumscl osLs of ennsotais rvoe aidlme 1 /12 nigefsr, ciungidln horpetyahn c.neeinme

sugaplum  Also to add: since it is a bilateral sx it is more likely to be coming from the spinal cord then from equal compression of ulnar nerve (in guyons canal) on both sides. unless she is a cyclist +20  
thefoggymist  shouldn't the other nerves of the same roots be affected? +  
thefoggymist  shouldn't the other nerves of the same roots be affected? +  
charcot_bouchard  Not really. In klumpeke paralysis ulnar nerve s/s dominates (Almost same cause) +  


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I otdn' teg t.his on'hltSdu teh sdeiynk artst girnoecrct eht aicbrb evslle rfae 5 da?ys The deydlea aheps of the ortricnoce sncie hyet ekat e.i.t.m and ni hte utnoesiq htere'y sgnaki en"o.W"w evha aemcbitlo asosklila iensc HCL is osl,t os the body liwl tyr to cecortr ti irsft yb ieantnivphretloy nda reatl by dcsraenei reneitcxo fo .irbacb bBraci dlouhs be .l.ow. l(esuns I'm imsinsg tsgniohme ude ot beign etdhsexau)

thefoggymist  Nevermind, I think I got it. Beta intercalated cells cannot function and excrete bicarb because we don't have chloride. Yea apparently I was exhausted. +