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 +2  (nbme21#34)

Why we have deposits in the glomerular membrane. It supposed to be subepithelial - spike and dome - granulations, right?

lovebug  @stefanmil Yap. you're right. I think "Spike and dome" @ EM. and Diffuse capillary and GBM thickening in @ LM. +

Subcomments ...

submitted by motherhen(41),

Kartagener syndrome, an autosomal recessive ciliary disorder. Presents with triad of chronic sinusitis, bronchiectasis and situs inversus.

Since the brother is known to be phenotypically normal, he can either be AA, Aa or Aa. Thus, there is a 2/3 chance is a carrier.

stefanmil  Can you explain how is this Kartagener? It didn't come to my mind at all :/ thanks +  
kcd0321  I thought it was Cystic fibrosis: chronic cough with "thick" green sputum, cramps in the abdomen (malabsorption issues because of pancreatic insufficiency maybe), and then the frequent respiratory infections. Its also AR so the same principle of AA, Aa, or Aa, so he has a 2/3 chance of being a carrier. +1