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Welcome to roygbiv’s page.
Contributor score: 20


Comments ...

 +0  (nbme24#4)
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yhW dluco stih not eb asraearltxvuc eohimsls?y In FA it ssya ctuea ltehyicom aufnssnrito atieonrc acn eb edu to BOA itmlnboaipctiiy ro aualcvaxstrer se.yomhlsi

niboonsh  because extravascular hemolysis is associated w jaundice. Intravascular hemolysis would have hemoglobinuria but that's not an answer +1
niboonsh  i mean that is the answer lol +
krewfoo99  According to pathoma: Intrvascular haemolysis will lead to haemoglobin binding to haptoglobin. This complex will travel to the kidneys and be excreted. This will lead to red colored urine and haemosiduria (Note: This can also lead to acute tubular necrosis) Extravascular haemolysis is when macrophages break down the RBC. Then the Haeme is converted to biliverdin then bilirubin and conjugated in liver, and then excreted. +4
paperbackwriter  If you look under the "clinical presentation" column of the blood transfusion reactions chart (pg114), it says that hemoglobinuria is with intravascular hemolysis and jaundice is with extravascular. Makes sense because with extravascular hemolysis your splenic macrophages are are chewing up the RBCs and sequestering it in the spleen so you don't get "spillover" -- i.e. clean urine. +1

hungrybox  not pictured: cremasteric a., which (I think) also would have been a valid answer +2
greentea733  This is great but honestly was this covered in ANY step 1 study resource? +8

 +2  (nbme24#17)
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zbird  So this patient has a leaking berry aneurysm which undergone to surgery and repaired but in two days she developed widening of the SA space which could be explained by increased CSF production but a decreased in absorption, which is due to blockage of the arachinoid granulations by the leaked red and white cells therefore there is a decreased movement of the CSF via the arachinoid villi +1




Subcomments ...

submitted by lsmarshall(396),
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"emesmosoD al(ucMa snradehe) - A tllolec--cle niecoocnnt thta vrdoipse tlrcuruast uprostp iwht dertimneieta flmina,ste apclryiltaur in stiusse thta oudgern mnleacihac rtesss ..,(ge ksni, sgairct eusst,i .eabr)ddl nsCcntoe yacrstiotnkee in hte mrustat snsiomup of het .r"epsemiid - SSAOMB

sympathetikey  This is why I was looking for some answer indicating keratinocytes in the stratum spinosum...instead they just gave a bunch of bs choices. +29  
roygbiv  I'm confused because I also know that S. aureus cleaves desmoglein in the stratum granulosum, so why is it specifically this answer? +2  
duat98  desomosomes connects cells to cells. hemidesmosome connects cells to basement membrane. +2  
medguru2295  I think what this is really asking is can you tell Pemphigus Vulgaris from Bullous Pemphigoid Vulgaris (question)- Attack on DESMOSOMES- this separates some keratinocytes from others (ie some in basal layer from ones above). Pemphigoid- attack on HEMIDESMOSOMES- this means separation of the keratinocytes from the basement membrane. +2  


submitted by xxabi(252),
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esrritAe fo eht cmtipsare dcro - celuasrtit a,. dcutsu drseenfe ,.a rctamcesier a.

roygbiv  https://i2.wp.com/obgynkey.com/wp-content/uploads/2017/06/A302767_1_En_1_Fig2_HTML.jpg?w=960 +1  
roygbiv  Omg I keep adding comments instead of a post LOL +4  


submitted by xxabi(252),
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esertirA of het eitsmpacr crod - rceltaiuts ,.a usudct enrdfese ,.a cmitsarecre .a

roygbiv  https://i2.wp.com/obgynkey.com/wp-content/uploads/2017/06/A302767_1_En_1_Fig2_HTML.jpg?w=960 +1  
roygbiv  Omg I keep adding comments instead of a post LOL +4  


submitted by lm4(9),
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wq=ghsmfwaps.rm+t?cebtt:+ua.tioyltle&r/opwrs+tpsetee/ol+ci=hatc/igsolhs

roygbiv  https://i2.wp.com/obgynkey.com/wp-content/uploads/2017/06/A302767_1_En_1_Fig2_HTML.jpg?w=960 +