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Welcome to nuket0wn’s page.
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submitted by rajkamal17(0),
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ryettP user mI’ signmis mtohisegn asicb h.ere Tsih asw CSC iadivngn teesbanm eebmmran tciltadifea yb ?hawt eTh ersnaw si weiontunoalrgd of dernEcah-i but I ugthhot ats’ht fro esmastsatest F(A 18 yssa os t.oo) I tkecdi eacedrdes amiinnl tscrroepe riconrc)t(e coz inaminl was fduno ni eebnasmt bmenmera. tA atels atth aws ym goinse.anr Ayn plhe ppercaetia.d kah!sTn

naughtyegg  Downregulating E-cadherin is the first step cancer takes toward metastasis because low E-cadherin helps invade the basement membrane -> eventually leads to spread of cancer elsewhere. Laminin is also involved but according to pathoma, cancer will actually attach to laminin in order to destroy the basement membrane. Idk if receptor up/downregulation happens, that might be a stretch. +16  
nuket0wn  per medbullets, there are increased laminin and integrin receptors. Also upregulated MMPs (matrix metallo-proteinases) to breakdown the basement membrane. +1  
nwinkelmann  It makes sense that a tumor cell would increase their laminin, as opposed to decreasing, if attaching to laminin is what allows the cells to destroy the basement membrane. The more laminin, the more destruction possible. +