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Contributor score: 8

Comments ...

 +0  (nbme20#10)

this dude had a complication aortic valve replacement which he now presents with a decrescendo diastolic murmur at the left sternal border (Aortic Regurg). The RBCs seem to get sheared as they pass thru the faulty opening of the replaced valve causing intravascular hemolysis

 +6  (nbme20#4)

Syringomyelia normally presents with bi-lateral loss of pain/temp in a cape like distribution due to damage of the anterior white commisures of the Spino-Thalamic Tract.

This person also has wasting of the small muscles of her hand, which is due to Syrinx expansion causing damage to LMNs of the anterior horn (from CNS Pathoma)

dbg  you're talented, bball and now this

Subcomments ...

submitted by hayayah(603),

Defective homologous recombination is seen in breast/ovarian cancers with the BRCA1 gene mutation.

johnthurtjr  Ashkenazi Jews have a higher risk of inheriting the BRCA1 and BRCA 2 gene mutations, just another tip! +  
lebron james  BRCA1/BRACA2 are involved in the repair of DNA double stranded breaks +2  
samsam3711  Other answers: DNA Mismatch Repair: Lynch Syndrome (MLH1, MSH2) DNA Nucleotide Excision Repair: Xeroderma Pigmentosa +1