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 +0  (nbme13#21)

2,3-BPG created in RBCs during glycolysis. The production of 2,3-BPG is increased when oxygen availability is reduced, as occurs in chronic lung disease, HF& chronic exposure to high altitudes. Elevated levels of 2,3-BPG decrease Hb O2 affinity, allowing the release of more O2 in the peripheral tissue

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