to snoo-finity ... and beyond!
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How do you differentiate this from hypertonicity of the internal anal sphincter?
To clarify Methotrexate (inhibits dihydrofolate reductase) and 5-FU (inhibits thymidylate synthase) in the Pyrimidine synthesis pathway.
6-MP inhibits Glutamine PRPP amidotransferase in the PURINE synthesis pathway
The give away is the Fever, Pancytopenia, and Hepatosplenomegaly after being bitten by an insect and developing the sore.
To add to ^
It is widely used (though off-label in many countries including the United States) in the treatment of hyponatremia (low blood sodium concentration) due to the syndrome of inappropriate antidiuretic hormone (SIADH) when fluid restriction alone has been ineffective. Physiologically, this works by reducing the responsiveness of the collecting tubule cells to ADH.
The use in SIADH actually relies on a side effect; demeclocycline induces nephrogenic diabetes insipidus (dehydration due to the inability to concentrate urine).
What does this have to do with the Celiac Sprue?
I believe they were explaining the reason for the mentioned "mild osteopenia" in the pt presentation.
No, I think this person got confused with another question about celiac sprue, PTH, Calcitriol, and Vit D (it was an arrow type question).