NBME 23 Presentation of antigens to CD8+ T lymphocytes (NBME Answers)

Retired NBME 23 Answers

nbme23/Block 1/Question#22 (reveal difficulty score)
An investigator is studying the adverse ...
Presentation of antigens to CD8+ T lymphocytes 🔍 / 📺 / 🌳 / 📖
tags: immuno repeat

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submitted by ∗sajaqua1(607)

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MHC I iuonnfct is nretagil ot cncrea ssrieospup.n CHM I diyaslps oeogyusnndle sndhiyesetz epronist dan spneestr thme ot D+8C T scl.le heT aleruif to paidsly MHC I, or HCM I ysdlaip fo lnsnoe-f (dan by soientxne uocrn)scea trneoips tgirgres a lrllcuea eummni os,pneres engiald ot nictdotresu fo eth cell.

hTe esemptoroa is seud rof teh rnaadodigte of wrno ,tuo ,nteencess or ermmoldaf .nortpeis sA arncce evosl,pde omer ismatnuto ldae ot resicaned wongr .rnsetiop Oynl by epineosrxs fo hte epma,rsooet ro tsi rern-opvixesseo, acn etesh ttuamn ponietrs eb erddedag fsat oneguh to otn be paidedysl yb CHM I dan dael ot eth llec gibne ll.kedi mztbioroBe coklsb hte pa,oerostme os teh antumt iosentpr rae lsyeidpad no eht ,caufers lanwloig the miuenm ysmset to zciegoren dan lkli lcgaioalptho secll.

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catch-22 Arnheot way to apcpahor ti is ot iknth autbo MHC lssac I eogscspinr. acByalil,s fi oyu ihnbtii hte otaom,peers dtsppeie illw ton eb eadgenret nad nitnhog si iballavae to eb ddaelo tnoo HMC I mem(rerbe MHC I hsa ot eb laedod eebfro ist' ardtnposrte to eth ellc u)scef.ar slelC hatt t'ndo serepxs HMC I etg ilekld yb eht laturan lr.sl eiktla3vMbliwcm//rm/:2hi.pwnsehPpin1c.6/ot/7sg4w2n/C.ct. +32

kai nI" colnn,sucio ew heav eamsonretddt taht eht eeamtropso iirhbonti emortobzib lsat-ernouegdw asscl I and naecshen eht vietysinits fo mymlaeo ot KN mc–idelaeedtl sli"ys fmro teh coioclnusn of the NIH prape +6

maddy1994 neohrat cmemnihsa si yb obkcingl mptreeooos u vnee daeescer iantoerdg fo ttoaporicppo r..tpoesnis.o ti cnceensah orosaf(pmptsoi w)dluor +6

azibird tBu +8DC and NK celsl llki iav firnor!ep yhW is sith sreanw ro?wgn sI it eeaubcs st'i tno eth rrmapyi ?fctefe +2

testready eT"h pootaseerm is eth mjrao rscoeu of tocpteyolri vctiaity ednivlvo ni eth inoeagernt of dtepeisp for peortnisntae by armjo psattoyiiihtimbclo lomcxpe sascl I osmcelle.u We roprte the ewn anreovibtso ttah tomzbeibor eugdlr-swetona AHL clssa I no MM elcl,s lrgitnesu in ciraneeds KN lemctladieed– y"lsi.sbmnnc//32/e.ticil/s.w:7Pph.2t1n6ao4tvilw/wprhsMCc/gm. +

fatboyslim I ihtkn thwa PO adis riactdstcno iwth waht 2c2h-act@ idtec in teh PMdeub retcial. +

an1 OP idsa nOy"l by inpsseeorx fo eth repaeomots, ro sit si,oorepxve-resn anc teesh muntat seirtnop eb gerdedad fsta geounh to not eb eispdydal by HMC ."I UW QDI 71164 asys tath a tepnoir esdnoguer dgadtoriena by the unqibtuii pmesorotae hyawpta, faret cihhw ti oges ot teh RE dan ehnt is sedeprnte to eth ecll fcrueas for MHC 1 rnesospe nidagle to soiasptop iva rfemrsop dan sea.nmrygz naviHg a emposareot ihiiotrbn wlodu acytllau rnvetep eth MHC resnospe cbsuaee no opetirsn are l.pydeiads osAl noet that the otuienqs asys hchiw cepsros lwli be ffeaed,ct hrtee is no inmoetn fo ersincae ro recas.eed oS ey,s teh HCM 1/ 8CD yasahptw si efdat,fec but i'st llcayuat dwno terle.duag An eebacns fo HMC 1 dslae to KN clel diteaedm ae.dht +

"Studies have shown that proteasome inhibitors block the assembly of MHC class I molecules and this is almost certainly because they are stopping the production of presented peptides that are needed for this process (6)." https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3094101/

+3/- donttrustmyanswers(74)

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submitted by ∗tinydoc(276)

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RsbzHtJhheUm/fI/5p3yot/:uu.t

MAO fo omsrpetooe nihortbiis for .MM LR:DT si hatt ehty icyaabsll lbokc eth pestoomroe frmo niontnfcgiu os htat myaoelm clesl ntc'a cyrelec rpntiose heyt( make a nto of me)ht adn ehnw yhet a'tnc be clcdeyer tehy biuld pu nad shtat iotxc ot the clle dna ti dies.

deynob hatt eth oestuiqn is abycalsil gsiakn if hte onhinibiti of esopremtsoo nist cpefcisi to teh maoMyel clels dan it htnidibei oreht clsle' osetmproeos htwa luwdo eb defte?fec

HCM slsca I is pteensr no all deeutcnla slecl a(ll lscle in eth obyd txeepc CR)B adn oucntifn ot eentspr duenngooes easintng to C+D8 t llesc ot be tdyodsree fo(r mlaxepe Vrila NAD ni an dntcfeie ll).ec hTe yaw htey do stih is yb tankgi eth oeipnrt ti eesnd ot spnrete and kaniegbr ti owdn iotn cmhu rmaslel tpepdei iachsn os( it can tfi on eth CIM.H If itsh pset was ebihdniti ni torhe slcel htne the the Pnansoetiert of CHM I lnwdotu eb ebla ot eetnpsr ierth sgentain ot +CD8 T llecs and aNluatr rllike ell.sc as eht tsnuqeoi .mlpisei

Teh etqnuosi aws rpseu rkiytc ebceasu if uoy dot'n nowk hwo oepmtoeosr tiinhibors rkwo hnet you artts gonokli ofr an esawrn ttah wuodl pilexan how ythe duolw likl omurt clsel sa w.lel I otg ti rnwog .too tI qreueidr eledokwgn fo teh ayw CMH I pnsseert tdpi.seep

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submitted by ∗krewfoo99(115)

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yWh dowlu rriseopfn be the onrwg ?ersanw Wdutoln lnmciauotcua fo ocxti rpiotnes ucsae het ellc ot ndoerug osppsotia ?

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ergogenic22 Boromteizb sedo ton yceditrl atievtca .roefprni It dyltrcie inshibit eth psamrteoeo hiwch → aeslneb DC+8 T eclls ot ettnaiii spsiopaot → aiv ropeinfr aeelers ni( esences a wanomstred .feft)ce +4

drzed tacx,yEl ti regirstg eht sllce ot nougerd ssotpioap ichhw masne atht it acn ihreet eb cell deeaitdm or(refinp dan nyrgezma avi FA)FSLSA/ RO ti loucd aosl be rohhgtu het intsiicrn pyahwat e..g( rd;oclomahiitn tecoyrmcho c) +

powerhouseofthecell nstueQo:i tBu owh od DC8 elscl aehv a olre in iths posresc yelaxct in the ?ivgetnte Is it snaigy atht nhew the prnioset lbdui ,up noly htne od CD8 clesl coem dna aneitsd of HCM I sitpegnrne ot s,meoaeotpsr etyh npteres it ot C8D to iitinate p?ptssioao +

flexatronn lrftcoeho@euwpslhoee o s ti lla goes acbk ot bacsi omuimn (i got hist wnrgo and ptu opsoatisp as wl)le tbu afrte rniviegew enlvaert iank crd,sa i onw teg Si.to soeemaoptrs rkeab ondw edgagt trnpsieo htiniw eth ellc nn(d.oeuesgo) eTh rwenbadok ordptusc tge tkean pu by arprtosnt ictoassaed wiht ginneat oiescgsrnp TPA)( nda tgohrbu to eht rugoh .ER hTe dkraneowb scudrtpo ear enht dleoad tono CMH I lesumceol and brotugh to eth eafrusc of eht .llce nheW nhntigik otuab MCH I, ikhnt boaut C8D+ T lcsel FA( CMH 1 x 8 = 8oC.wDN ot ,azrmseimu wneh nusgi a msreoetoap rni,biohit reuoy' gblonkic ttha iagtggn adn HMC I oadilng r.pseosc sA taedts rfebo,e D8C iznecroegs HMC I (chihw wont' hpaenp nweh insug sheet rsd)ug +3

whosdaprincesss ftnl@exnrao athkn uyo !!!! +

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submitted by ∗abhishek021196(120)

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,borimeoBzt ibiczofmlar

aimsMehnc = raoemPoste brtihni,ios ecindu eartrs at 2MG- sheap nad spo.sitaop

esU = tlMueipl lmaym,oe mletna ecll .mymaohpl

dvA ceEfstf = rrPeaplhei pohtrnayeu, perhse srzote eatirtovcani

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tyrionwill druen i,tebozBrom teh sertopoaem nnaoct isgdte arilv gA dna ptrensse it to eht enrmmbobaed-nde .HIMC- eTfhrreeo TDCc8- catonn nirozeecg teh hsto esllc nogtiiannc rpsledae ZV.V htTa is pblboray hyw nglsehsi is neo fo het lpuroap iesd teffce fo to.mzBeiobr +

kcyanide101 eTh rdgu iinhitbs .eomsoproet neecH htere si on namrfetg balvlaeai ghoutrh TAP indesi DC4 lcle ot ldao ntou CMH ...I. sA cush eth CD8 opetensiantr ot lTlce si ve.dpenrte ehT nulcugatmcai tnipsroe sinedi hte DC8 lecsl hwhic ear ton ebngi koenbr wond yb hte soteeprmoo ueasc it ot rgeondu tissapoop +

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