This is a woman with sarcoidosis, as suggested by her hypercalcemia and noncaseating granulomas. The normal demographic for this is an older African-American woman.
In sarcoidosis, there is increased 1,25-(OH)2-vitamin D (active form), leading to increased calcium resorption in the intestine (leading to hypercalcemia). This increased calcium has negative feedback on PTH hormone release, leading to decreased PTH levels as well.
submitted by โbingcentipede(356)
This is a woman with sarcoidosis, as suggested by her hypercalcemia and noncaseating granulomas. The normal demographic for this is an older African-American woman.
In sarcoidosis, there is increased 1,25-(OH)2-vitamin D (active form), leading to increased calcium resorption in the intestine (leading to hypercalcemia). This increased calcium has negative feedback on PTH hormone release, leading to decreased PTH levels as well.