NBME 16 Induction of cytochrome P450 enzymes that activate acetaminophen to a hepatotoxic metabolite (NBME Answers)

need help with your account or subscription? click here to email us (or see the contact page)

search for anything ⋅ score predictor (“predict me!”)

NBME 16 Answers

nbme16/Block 3/Question#1 (reveal difficulty score)
A 20-year-old man is brought to the physician ...
Induction of cytochrome P450 enzymes that activate acetaminophen to a hepatotoxic metabolite 🔍 / 📺 / 🌳 / 📖
tags:

+10 upvote downvote
submitted by ∗hungrybox(1277)

get full access to all content ⋅ pick a username

ACUTE alcohol inhibits CYP → Increased bioavailability of acetominophen

CHRONIC alcohol induces CYP → Induction of cytochrome P450 enzymes that activate acetaminophen to a hepatotoxic metabolite

I got this wrong because I assumed chronic alcohol meant years and years. I guess a weekend will suffice?

Honestly, fuck this problem.

get full access to all content ⋅ pick a username

lfcdave182 Yeah fuck this question. 2-3 days of something would never be considered chronic in anything else. +6

pontiacfever Drink a lot for a week makes you a chronic alcoholic? +1

pontiacfever That means alcohol abuse = chronic alcoholism +2

skilledboyb Why would increased bioavailability of acetaminophen place the patient at increased risk of liver injury? What's dangerous about that? +

i_hate_it_here Metabolism of acetaminophen turns it into toxic metabolites (NAPQI) that inhibit glutathione in the liver forming toxic tissue products. FA2020 pg: 485 +3

+1 upvote downvote
submitted by ∗feliperamirez(45)

get full access to all content ⋅ pick a username

Acetaminophen is mainly glucuronidated and minimally metabolized to NAPQI by CYP 450 enzymes

Chronic alcohol consumption induces CYP 450, so more acetaminophen is metabolized to NAPQI

get full access to all content ⋅ pick a username

detayo Would this qualify as chronic alcohol though? +12

detayo Would this qualify as chronic alcohol though? +

Must-See Comments from nbme16

zincy7 on Gastrin
bingcentipede on Cerebral edema
cassdawg on Kidney
medninja on Lysosomes
cassdawg on Sildenafil
cassdawg on Feces-contaminated soil
cassdawg on Peutz-Jeghers
cassdawg on Presence of an internal ribosome entry site
hungrybox on Induction of cytochrome P450 enzymes that ...
andro on Antagonizes VLDL-cholesterol secretion
bingcentipede on Decreased function of Na+–K+ ATPase
bingcentipede on Glyceraldehyde-3-phosphate dehydrogenase
cassdawg on 46,XXY
bingcentipede on Grade 4/6, holosystolic murmur heard best ...