The proximal tubule is the site of reabsorption of the majority of electrolytes (HC03- Na+, CI-, P043-, K+), water uric acid, glucose, and amino acids in the initial glomerular filtrate.
It requires a decreased intracellular sodium concentration generated by the Na/K+-ATPase pump and thus is sensitive to hypoxia. ("anoxic injury")
submitted by โbingcentipede(356)
The two sections of the nephron most susceptible to hypoxic conditions are the 1) proximal convoluted tubule and the 2) mTAL (medullary section of the thick ascending loop of Henle)