Congenital neutropenia is defined as neutropenia that is present at or around the time of birth, is not related to a secondary cause, and persists.
In cases of mild neutropenia, symptoms are less common, although patients may eventually develop stomatitis and gastrointestinal ulceration.
In severe cases, there is a substantially heightened risk for invasive bacterial infection.
submitted by โcassdawg(1780)
Segmented neutrophils should be the largest population of leukocytes. This girl has had a very low neutrophil population since birth, indicative of congenital neutropenia. All other cell counts are normal (RBC count and hematocrit at birth are actually high but normalize by 1 month).
None of the other disorders would cause severe neutropenia. SCID and DiGeorge are more likely to have lymphopenia. Congenital CMV causes hearing loss, seizures, rash, chorioretinitis, and periventricular calcifications. Alloimmune hemolytic disease of the newborn would present with anemia.