NBME 20 Increased osteoclast maturation and activity (NBME Answers)

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NBME 20 Answers

nbme20/Block 2/Question#7 (reveal difficulty score)
A 30-year-old man comes to the physician ...
Increased osteoclast maturation and activity 🔍 / 📺 / 🌳 / 📖
tags: endo PTH

+11 upvote downvote
submitted by cafeaulait(11)

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I eiveble hsit setm yma eb rniifnger MNE 1 onedrsym - lpiosesb sgtoarmina pt(icpe rcelu iedesas xd), oihpdyrraat n,aaemod nad tyirupati damaneo uasic(gn DH).ASI tuB, ouy 'dtno edne to vnee nowk hsit to gte sith grtih - stju inkgsa eht eefcft fo hihg PHT on teh msytes - causes saneiderc acesostotl iictatyv sa ewll as rauatti.mno

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fatboyslim heT smpsotym of sthi ipteatn era due to lceahpimycrae esots(n, ,senob nso,rag TSOHENR adicre[nse disr,uei}s nad ptrcciaiysh t)oneeo.rvs calcyipmerHea cna salo sucae epcpit ecurl ieds.ase So teh yrrampi ogtlayohp si rotaiarphyd n/adeaspmaeplhoryai scnuaig het lchaacrmeiepy +6

beetbox Deso naynoe nwko satw'h pu ithw the o'n atinsebrmaloi in uuerhms i?rdDayX' yhte sjtu owrht htta ni rfo on as?oern I otg hdekoo on ,ti I utghhto there saw on andrieecs eosctolsat ac.ityvt.i. wtierehso the lcaitcro bneos lwoud aevh been ydlod tnhi ro eghtmnsoi +4

topgunber ENM 1 - P P P . taPoirrhay,d nsrgrctaeipnsaa( in tshi )eca,s tutirypai neil.os tno eky ot argseinnw htis qnuspto t.ie ocems thwi mmtpssyo fo rmael,cpahcyei s,naom rngosa, snoetrh ein(gp,)e pycsh eLveooknost .ro ta tph nda umlcca.i we see ighh ac dan ihhg ht.p eW nkwo htta hhgi ailcucm duwol orelw i.htst.p.h smaen hte ghih acuciml asw edu ot teh hgih pth (.ie. iophradatry unee Qsaatdmio)no is lyltacua skga:ni hawt aer hte efesfct fo PTH? a, c, poositpe fo DTP H nad E i ebvdeeli e'atnr daretle ot soTH-BSdnu P ghtemsnio kile eth santigpeesho fo oesupFaahrtph esddoipmiyy-r ew nedifetily knwo hatt HTP nciasrsee Ca , so by rsiencngia otscoaslet ymcitnvuitatirt/oaa uyo abeelitr uimaclc otni hte bl.odo stih si hte tsbe eanswr. +3

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submitted by ∗laminin(18)

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nca seemnoo apeinxl hwy ti assy he has an ita'cnt' THP iocn.itoen.tsc.nar ti to let su kown ahtt teh HTP nntcrotcoaein is a ltsrue of ta agdhnlopoy? 'twhsa ish d?x !nhatsk

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yotsubato I rwase heyt kame pu esom of shit tff.su Leki ahwts up wiht hte tihrts, n,utiaiorn nda cietpp uerlc essseai.d +9

redvelvet eiapelhmyracc can aseuc eehrpncniog asetibde ssdpu;ini os sttrhi, aiu.ritnon lyrecpaemahci cna asol scaeu ptpice rleuc esisd.ea iHs mmpstoys rea lla autob aaicleeyrpmhc ued ot psptiyrmraydhriaeh.o +4

namira i"pcclryaHamee nca aescu narel oytunncsdfi uhcs sa peehgnicrno tsadeibe disunpisi (DI),N utb het shmaescimn ignnyrldeu ecydmliaiencephcar-du IDN ear ont ellw dsor oud.ten"k(.o1/x8:8w2)3iplSecr6nennd.w0tuw9e-0atgt5i5/0ts0ir/teahlyrlt7a43--//tnfoil +2

dulxy071 hyW a'tcn hte rcoectr easrnw be )C hciwh tisnpo dorawts renal i,ufaerl icwhh may leda ot ocarynsde msypioyarahephdrtri hvgina hte amse essrtlu I leivbee +2

pmofmalasia Teh oeyrnasdc ahpyemarosdhityrrpi ni lanre leiafur is deu ot osls fo lcacmiu ni the oitonunnn-cnfig yed.ikn In stih etquosni eth lacmciu swa d,laeeevt so ouy nca luer otu raenl ealurfi. +1

sars peil-Hamrcayec suecas sntseo lai(ccmu osens,t) asgonr )i,ciosaopn(tnt sehntor esedcrani( no,iutir)an esbon i(eansdcre eacotostsl c)ivitao,ant dna htaprsciyci verotnseo resp(oidns.)e +1

epiglotitties osobuy@tta lsoa as seeoonm deiemnnot ni tnhaeor m,tecmno i hitkn e'hyter inhigtn taht teh xp gmtih aveh NEM.1 hyadarPriot aapiplhsy-re cleyarmcihe,ap ryiapuitt -emanoad SAIHD uot+(,in)iasnhrritt dan aanptcrcie umrt-o arnmosigat tecip(p ceurl )eseaisd +

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submitted by killme(14)

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Teh toencpc bnieg tetesd si thw"a sdeo TPH od atht desla to r "aycheiceampldbtj.3e/nt/s.cVb./K/giohpPi:ipmsag

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yotsubato ,hgu sul.bilth I aws ytgrni ot feriug tou an taaluc eseiads scsoepr r.hee +7

rio19111 tis yapimrr ohrtrappryhiymesadi acduse yb aiyrarhoptd ema.dona diodntai of the tpepci rucel gtssuge gnrZoeill -;-&tg- 1EMN utb eonn fo atht si mpi busceea 'tatsh ton athw hyte era nsgka.i All eyht rae sakgin ofr is het ftcnunio of P.HT +3

topgunber NEM 1 - P P P . yht,riaPoadr nasapsrteacnir(g ni ihts asc,e) aityupitr eons.li ont yke to nngreaiws this otqiesu.pt n ceosm thwi smyptmos fo ec,amepcihylra msna,o onasr,g therons (ie)epn,g yscph voooLo.neste kr at tph adn liu.ccam we ese high ca nad ighh tp.h We nokw thta gihh ilacucm uoldw elorw .si.tpthh. asenm the high luacimc asw edu to teh hghi thp (e.i. dptaaoyirhr )nunQeoitosadmea is yaclutal igank:s wtah rea het esfetfc of PT?H a, c, potesiop of PD TH adn E i iveleebd ane'tr deartel to uHBsnPodS T- ntmesihog lkei het teosspheagin of pysopdmiaespyauot-eh idrFrh ew tiieldefyn nkwo htat PHT acisrsene aC , os by regnaiicns scalosotte iyiotvratnamtaiut/c yuo arbtliee muccial tnio the old.ob iths si teh sbte ar.nwes +1

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+2 upvote downvote
submitted by ∗sympathetikey(1600)

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In idotaidn ot THP = tslacosoet aicvyitt = cedrniase ,micucal sthi epnosr oucld sola eb xtiihnibeg tmoysspm of .MNE1

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topgunber NEM 1 - P P P . itayaPdroh,r esictnsgrraap(an in this sec,)a rptityiua n.liose ont eky to ansiwergn this i tp.ouseqtn omces htwi pmsosymt fo camhleya,crepi n,saom gr,asno toesrhn )p(enie,g cpshy L ots.overokeon ta tph nad .cuicalm we ese ghih ac dna ihhg tp.h We nkow hatt hhig mccailu duowl olrew i.ph.h.tts namse eht ghhi lmacciu was eud ot het ihgh htp ie.(. pryioarthad )enoudai teaosmnQ is cyatllua :knsaig twah are the eecftfs of TP?H a, ,c seootppi fo HDT P dan E i iedebvle 'trnae tadelre to HuS Bs-PnodT neghositm eikl het ehtgnipsesao fo oreFshs -idapmrhyydoaueppit ew yfetiiednl onwk ttha PTH eicsnesra Ca , so by enngicisar loectsstao iracyoi/mtuttaatvin uoy ieatlerb calmuic iotn eth oobld. tshi is hte tesb sw.rena +1

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+1 upvote downvote
submitted by rio19111(16)

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tsi yriarpm iierhrrptyaapmysdoh seucda by trpihardoya demoaan. aitdniod of teh ppctei rulce gteguss lrngioZle gt-&;-- MEN1

utb nnoe of that is pmi cbeseua 'tatsh otn waht tehy rea gkn.ais All ehty era nkagsi ofr is the foinuntc of TPH.

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rio19111 enost,S rsaogn, reht,nso ircithapycs osorenevt ;&-tg-- stymomps +1

topgunber MEN 1 - P P P . y,raidahPtor rnnpsa(esraiacgt in ihts scae), pruyiitta esli.no nto kye to rwansgnei tsih i opsqetut.n secom tihw msmptsoy fo ,cpayraelhecmi omas,n o,nsrga setnroh e)pen,(gi pyshc tvoL so.enkeoro ta hpt nda .liamccu we ese hhgi ac dna ihhg h.pt eW ownk tath hihg cclaimu wduol eworl sh.iht.pt. nesam het hhgi uimclac asw deu to teh ihgh thp .ie(. rryitopahda doQieem)n oanastu is lcytulaa iankgs: athw aer hte tffeecs fo ?HPT a, c, eoiotspp fo HDPT and E i lebediev atre'n elaetdr to nBodsHSPu -T ntoeghsmi ekil teh nepihetgsaso fo ypdoemtorhspep a-yisuFdirah we yiieeldtnf kwno taht PTH seesrinac aC , os yb rinneigasc ctoetsaslo mtrtuanoyaaiiiv/ctt you atelerib cmucali noit hte odo.bl this si het bets .wesarn +1

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submitted by ∗nwinkelmann(366)

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oeDs nneyao onkw het ceiinsficagn fo mntyoeco mtyl?ioit

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submitted by arthur_albuquerque(1)

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ahWt dehpel em to asernw iths eno qtiue iseyal swa teh nolfiwlgo an:eotrail

clHyeiacerpam + ighh HTP ;-t&g raryim"p aiahiopptysermrry"dh

wHo do ihgh THP ldae ot m?phiaeraelccy crangneIis tasoocelts iytvtc!ai

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submitted by ∗topgunber(67)

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MEN 1 - P P P . yih,draPatro gnssria(pacrneta in tihs ca)se, apiitutyr eoin.sl otn key ot asnegiwrn ihst oniteu.sq

tp ceosm ihwt pomtsmsy of e,laehmiracypc ,soman ,arosgn ontersh i,pen()eg yhscp .enstorvoe

ookL at tph dan .ccumial we ees high ac nad hghi .pht We nowk that ighh miccual uodlw orlwe .ih.stt.ph msnea the high cmlcuia was deu ot the ighh tph ei(.. rpyaiohadrt oenamd)a

inQosuet is lcutaaly gnsa:ki hatw rae teh eetsffc of H?PT a, ,c ptoesiop of PHT

D adn E i lebdevei tnrae' erdatle ot PHT

sunBd-So msteonhig lkie the eiestsopanhg fo phutaosyodriesidpreyamph

-F ew yeldntfiei kwno atth HPT srneiseca Ca , so yb anigsncire leoasottcs aaaimctoyirvutntt/i uyo eitlebar umilacc tion the blodo. isht is teh steb res.naw

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